Research
Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital
Published

Possible role of histamine in pathogenesis of autoimmune diseases: implications for immunotherapy with histamine-2 receptor antagonists.

Research output: Contribution to journalJournal articleResearch

  1. Involvement of steatosis-induced glucagon resistance in hyperglucagonaemia

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. insulin plays a permissive role for the vasoactive effect of GIP regulating adipose tissue metabolism in humans

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Myogenic and metabolic feedback in cerebral autoregulation: Putative involvement of arachidonic acid-dependt pathways

    Research output: Contribution to journalJournal articleResearchpeer-review

  1. Gel-Based Proteomics of Clinical Samples Identifies Potential Serological Biomarkers for Early Detection of Colorectal Cancer

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Evaluation of algorithm development approaches: Development of biomarker panels for early detection of colorectal lesions

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Genome-wide cell-free DNA fragmentation in patients with cancer

    Research output: Contribution to journalLetterResearchpeer-review

View graph of relations
The immunosuppressive chemical drugs cyclosporine A (CsA) and methotrexate (Mx) have recently been shown to be of benefit in several different diseases of autoimmune origin. Cellular immune responses may play a major role in autoimmunity as autoreactive T lymphocytes appear to recognize autoantigens and major histocompatibility complex (MHC) class II restriction molecules presented by non-immune, aberrant cells, subsequently leading to damage on healthy tissues. Psoriasis is suggested to be an autoimmune disease and in severe, uncontrollable psoriasis CsA and Mx are of value in reducing disease activity. Histamine is suggested to be involved in the pathogenesis of psoriasis and the histamine-2 receptor antagonist ranitidine has been shown to be of value to reduce severe psoriatic disease. The finding that CsA and Mx efficiently reduce histamine formation and release raises the possibility, that histamine is one of the molecules involved in pathogenesis of autoimmune diseases. T cell mediated regulation and suppression of autoreactive T cells seem to be ineffective in controlling the enhanced immune reaction in patients where the discrimination between self and non-self is changed. A consequence of this may be induction of interferon-gamma (IFN-g) production and release by cytotoxic T cells, subsequently leading to expression of MHC II molecules on non-immune tissues. As immunotherapy may be of value in some autoimmune diseases the use of histamine-2 receptor antagonists should be evaluated in patients where conventional therapy is ineffective to reduce disease activity.
Translated title of the contributionPossible role of histamine in pathogenesis of autoimmune diseases: implications for immunotherapy with histamine-2 receptor antagonists.
Original languageEnglish
JournalMedical Hypotheses
Volume39
Issue number4
Pages (from-to)349-355
Number of pages7
ISSN0306-9877
Publication statusPublished - 1992

ID: 32524127