Research
Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital
Published

Possible Prevention of Diabetes with a Gluten-Free Diet

Research output: Contribution to journalReviewResearchpeer-review

DOI

  1. PPARs and the development of Type 1 Diabetes

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Fenofibrate increases very-long-chain sphingolipids and improves blood glucose homeostasis in NOD mice

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. L-serine: a neglected amino acid with a potential therapeutic role in diabetes

    Research output: Contribution to journalReviewResearchpeer-review

  4. Investigating the aetiology of adverse events following HPV vaccination with systems vaccinology

    Research output: Contribution to journalReviewResearchpeer-review

  5. Oral LPS Dosing Induces Local Immunological Changes in the Pancreatic Lymph Nodes in Mice

    Research output: Contribution to journalJournal articleResearchpeer-review

View graph of relations

Gluten seems a potentially important determinant in type 1 diabetes (T1D) and type 2 diabetes (T2D). Intake of gluten, a major component of wheat, rye, and barley, affects the microbiota and increases the intestinal permeability. Moreover, studies have demonstrated that gluten peptides, after crossing the intestinal barrier, lead to a more inflammatory milieu. Gluten peptides enter the pancreas where they affect the morphology and might induce beta-cell stress by enhancing glucose- and palmitate-stimulated insulin secretion. Interestingly, animal studies and a human study have demonstrated that a gluten-free (GF) diet during pregnancy reduces the risk of T1D. Evidence regarding the role of a GF diet in T2D is less clear. Some studies have linked intake of a GF diet to reduced obesity and T2D and suggested a role in reducing leptin- and insulin-resistance and increasing beta-cell volume. The current knowledge indicates that gluten, among many environmental factors, may be an aetiopathogenic factors for development of T1D and T2D. However, human intervention trials are needed to confirm this and the proposed mechanisms.

Original languageEnglish
JournalNutrients
Volume10
Issue number11
Pages (from-to)1746
Number of pages20
ISSN2072-6643
DOIs
Publication statusPublished - 13 Nov 2018

    Research areas

  • Animals, Diabetes Mellitus/prevention & control, Diet, Gluten-Free, Female, Humans, Pregnancy, Prenatal Nutritional Physiological Phenomena

ID: 56440800