Abstract
We describe a case of recurrent catheter-related blood stream infections (BSI) with Staphylococcus aureus, in which the first isolate tested susceptible to penicillin, while subsequent isolates were resistant. Phenotypic susceptibility correlated with the absence/presence of the blaZ gene. The in vitro stability of penicillin resistance was investigated by subculturing single colonies. In two out of five colonies, phenotypical resistance was lost after a single subculture, which correlated with loss of the blaZ gene. This in vitro phenomenon probably resulted in a very major error in the microbiology report of the first BSI, where penicillin had been recommended as treatment.
| Original language | English |
|---|---|
| Journal | European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology |
| Volume | 41 |
| Issue number | 1 |
| Pages (from-to) | 163-167 |
| Number of pages | 5 |
| ISSN | 0934-9723 |
| DOIs | |
| Publication status | Published - Jan 2022 |
Keywords
- blaZ
- In vitro susceptibility testing
- PSSA PRSA
- Staphylococcus aureus
- Blood/microbiology
- Catheter-Related Infections/drug therapy
- Humans
- Anti-Bacterial Agents/pharmacology
- Staphylococcal Infections/drug therapy
- Microbial Sensitivity Tests
- Bacterial Proteins/genetics
- Penicillin Resistance
- Staphylococcus aureus/drug effects
- Penicillins/pharmacology
- Bacteremia/drug therapy
- beta-Lactamases/genetics
Fingerprint
Dive into the research topics of 'Possible misinterpretation of penicillin susceptibility in Staphylococcus aureus blood isolate due to in vitro loss of the blaZ gene'. Together they form a unique fingerprint.Cite this
- APA
- Standard
- Harvard
- Vancouver
- Author
- BIBTEX
- RIS