TY - JOUR
T1 - Position paper
T2 - Rationale for the treatment of Wilms tumour in the UMBRELLA SIOP-RTSG 2016 protocol
AU - van den Heuvel-Eibrink, Marry M
AU - Hol, Janna A
AU - Pritchard-Jones, Kathy
AU - van Tinteren, Harm
AU - Furtwängler, Rhoikos
AU - Verschuur, Arnauld C
AU - Vujanic, Gordan M
AU - Leuschner, Ivo
AU - Brok, Jesper
AU - Rübe, Christian
AU - Smets, Anne M
AU - Janssens, Geert O
AU - Godzinski, Jan
AU - Ramírez-Villar, Gema L
AU - de Camargo, Beatriz
AU - Segers, Heidi
AU - Collini, Paola
AU - Gessler, Manfred
AU - Bergeron, Christophe
AU - Spreafico, Filippo
AU - Graf, Norbert
AU - International Society of Paediatric Oncology — Renal Tumour Study Group (SIOP–RTSG)
PY - 2017/12
Y1 - 2017/12
N2 - The Renal Tumour Study Group of the International Society of Paediatric Oncology (SIOP-RTSG) has developed a new protocol for the diagnosis and treatment of childhood renal tumours, the UMBRELLA SIOP-RTSG 2016 (the UMBRELLA protocol), to continue international collaboration in the treatment of childhood renal tumours. This protocol will support integrated biomarker and imaging research, focussing on assessing the independent prognostic value of genomic changes within the tumour and the volume of the blastemal component that survives preoperative chemotherapy. Treatment guidelines for Wilms tumours in the UMBRELLA protocol include recommendations for localized, metastatic, and bilateral disease, for all age groups, and for relapsed disease. These recommendations have been established by a multidisciplinary panel of leading experts on renal tumours within the SIOP-RTSG. The UMBRELLA protocol should promote international collaboration and research and serve as the SIOP-RTSG best available treatment standard.
AB - The Renal Tumour Study Group of the International Society of Paediatric Oncology (SIOP-RTSG) has developed a new protocol for the diagnosis and treatment of childhood renal tumours, the UMBRELLA SIOP-RTSG 2016 (the UMBRELLA protocol), to continue international collaboration in the treatment of childhood renal tumours. This protocol will support integrated biomarker and imaging research, focussing on assessing the independent prognostic value of genomic changes within the tumour and the volume of the blastemal component that survives preoperative chemotherapy. Treatment guidelines for Wilms tumours in the UMBRELLA protocol include recommendations for localized, metastatic, and bilateral disease, for all age groups, and for relapsed disease. These recommendations have been established by a multidisciplinary panel of leading experts on renal tumours within the SIOP-RTSG. The UMBRELLA protocol should promote international collaboration and research and serve as the SIOP-RTSG best available treatment standard.
KW - Journal Article
KW - Review
UR - https://www.scopus.com/pages/publications/85035355420
U2 - 10.1038/nrurol.2017.163
DO - 10.1038/nrurol.2017.163
M3 - Review
C2 - 29089605
SN - 1759-4812
VL - 14
SP - 743
EP - 752
JO - Nature reviews. Urology
JF - Nature reviews. Urology
IS - 12
ER -