Population-based head-to-head comparison of the clinical characteristics and epidemiology of AQP4 antibody-positive NMOSD between two European countries

Papp Viktoria; Kim D P Trones; Melinda Magyari; Nils Koch-Henriksen; Anna Iljicsov; Cecilia Rajda; Helle H Nielsen; Gabor Lovas; Csilla Rozsa; Bjørn H Kristiansen; Egon Stenager; Jette L Frederiksen; Samuel Komoly; Finn Sellebjerg; Thor Petersen; Zsolt Illes

doi:10.1016/j.msard.2021.102879

Population-based head-to-head comparison of the clinical characteristics and epidemiology of AQP4 antibody-positive NMOSD between two European countries

Papp Viktoria, Kim D P Trones, Melinda Magyari, Nils Koch-Henriksen, Anna Iljicsov, Cecilia Rajda, Helle H Nielsen, Gabor Lovas, Csilla Rozsa, Bjørn H Kristiansen, Egon Stenager, Jette L Frederiksen, Samuel Komoly, Finn Sellebjerg, Thor Petersen, Zsolt Illes

Neurology, Department of

Abstract

BACKGROUND: Population-based clinical studies in neuromyelitis optica spectrum disorder (NMOSD) and epidemiological and clinical comparisons of White ethnicities are missing. In a large population-based international cohort, we extensively characterized aquaporin-4 antibody seropositive (AQP4-Ab+) NMOSD, and also compared the clinical, radiological and epidemiological features between two European populations residing in different areas.

METHODS: Between self-reported Danish and Hungarian ethnicities, we compared the population-based clinical features, disability outcomes, and death of 134 AQP4-Ab+ NMOSD cases fulfilling the 2015 International Panel for NMO Diagnosis (IPND) criteria. For precise comparison of epidemiology, we conducted a population-based head-to-head comparative study of the age-standardized prevalence (January 1, 2014) and incidence (2007-2013) of AQP4-Ab+ NMO/NMOSD among adults (≥16 years) in Denmark (4.6 million) and Hungary (6.4 million) by applying 2015 IPND (NMOSD) criteria and 2006 Wingerchuk (NMO).

RESULTS: Danes were more likely to present with transverse myelitis and were more affected by spinal cord damage on long-term disability. Hungarians presented most often with optic neuritis, although visual outcome was similar in the groups. No differences were observed in sex, disease course, relapse rate, autoimmune comorbidity, mortality, brain MRI, and treatment strategies. The age-standardized prevalence estimates of AQP4-Ab+ NMOSD (2015 IPND criteria) in Denmark vs. Hungary were 0.66 vs. 1.43 (/100,000) while incidence rates were 0.04 vs. 0.11 (/100,000 person-years); similar differences were found based on the 2006 NMO criteria.

CONCLUSIONS: This head-to-head comparative study indicates different disease characteristics and epidemiology among White populations in Europe, and substantiates the need for population-based genetic and environmental studies in NMOSD.

Original language	English
Article number	102879
Journal	Multiple Sclerosis and Related Disorders
Volume	51
Pages (from-to)	102879
ISSN	2211-0348
DOIs	https://doi.org/10.1016/j.msard.2021.102879
Publication status	Published - Jun 2021

Keywords

Adolescent
Adult
Aquaporin 4
Autoantibodies
Denmark/epidemiology
Europe/epidemiology
Humans
Hungary
Neuromyelitis Optica/diagnostic imaging

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10.1016/j.msard.2021.102879

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Viktoria, P., Trones, K. D. P., Magyari, M., Koch-Henriksen, N., Iljicsov, A., Rajda, C., Nielsen, H. H., Lovas, G., Rozsa, C., Kristiansen, B. H., Stenager, E., Frederiksen, J. L., Komoly, S., Sellebjerg, F., Petersen, T., & Illes, Z. (2021). Population-based head-to-head comparison of the clinical characteristics and epidemiology of AQP4 antibody-positive NMOSD between two European countries. Multiple Sclerosis and Related Disorders, 51, 102879. [102879]. https://doi.org/10.1016/j.msard.2021.102879

Population-based head-to-head comparison of the clinical characteristics and epidemiology of AQP4 antibody-positive NMOSD between two European countries. / Viktoria, Papp; Trones, Kim D P; Magyari, Melinda et al.

In: Multiple Sclerosis and Related Disorders, Vol. 51, 102879, 06.2021, p. 102879.

Research output: Contribution to journal › Journal article › Research › peer-review

Viktoria, P, Trones, KDP, Magyari, M , Koch-Henriksen, N, Iljicsov, A, Rajda, C, Nielsen, HH, Lovas, G, Rozsa, C, Kristiansen, BH, Stenager, E, Frederiksen, JL, Komoly, S, Sellebjerg, F, Petersen, T & Illes, Z 2021, 'Population-based head-to-head comparison of the clinical characteristics and epidemiology of AQP4 antibody-positive NMOSD between two European countries', Multiple Sclerosis and Related Disorders, vol. 51, 102879, pp. 102879. https://doi.org/10.1016/j.msard.2021.102879

@article{9a58bf9c517746d3a253cc145376f1e0,

title = "Population-based head-to-head comparison of the clinical characteristics and epidemiology of AQP4 antibody-positive NMOSD between two European countries",

abstract = "BACKGROUND: Population-based clinical studies in neuromyelitis optica spectrum disorder (NMOSD) and epidemiological and clinical comparisons of White ethnicities are missing. In a large population-based international cohort, we extensively characterized aquaporin-4 antibody seropositive (AQP4-Ab+) NMOSD, and also compared the clinical, radiological and epidemiological features between two European populations residing in different areas.METHODS: Between self-reported Danish and Hungarian ethnicities, we compared the population-based clinical features, disability outcomes, and death of 134 AQP4-Ab+ NMOSD cases fulfilling the 2015 International Panel for NMO Diagnosis (IPND) criteria. For precise comparison of epidemiology, we conducted a population-based head-to-head comparative study of the age-standardized prevalence (January 1, 2014) and incidence (2007-2013) of AQP4-Ab+ NMO/NMOSD among adults (≥16 years) in Denmark (4.6 million) and Hungary (6.4 million) by applying 2015 IPND (NMOSD) criteria and 2006 Wingerchuk (NMO).RESULTS: Danes were more likely to present with transverse myelitis and were more affected by spinal cord damage on long-term disability. Hungarians presented most often with optic neuritis, although visual outcome was similar in the groups. No differences were observed in sex, disease course, relapse rate, autoimmune comorbidity, mortality, brain MRI, and treatment strategies. The age-standardized prevalence estimates of AQP4-Ab+ NMOSD (2015 IPND criteria) in Denmark vs. Hungary were 0.66 vs. 1.43 (/100,000) while incidence rates were 0.04 vs. 0.11 (/100,000 person-years); similar differences were found based on the 2006 NMO criteria.CONCLUSIONS: This head-to-head comparative study indicates different disease characteristics and epidemiology among White populations in Europe, and substantiates the need for population-based genetic and environmental studies in NMOSD.",

keywords = "Adolescent, Adult, Aquaporin 4, Autoantibodies, Denmark/epidemiology, Europe/epidemiology, Humans, Hungary, Neuromyelitis Optica/diagnostic imaging",

author = "Papp Viktoria and Trones, {Kim D P} and Melinda Magyari and Nils Koch-Henriksen and Anna Iljicsov and Cecilia Rajda and Nielsen, {Helle H} and Gabor Lovas and Csilla Rozsa and Kristiansen, {Bj{\o}rn H} and Egon Stenager and Frederiksen, {Jette L} and Samuel Komoly and Finn Sellebjerg and Thor Petersen and Zsolt Illes",

note = "Copyright {\textcopyright} 2021. Published by Elsevier B.V.",

year = "2021",

month = jun,

doi = "10.1016/j.msard.2021.102879",

language = "English",

volume = "51",

pages = "102879",

journal = "Multiple Sclerosis and Related Disorders",

issn = "2211-0348",

publisher = "Elsevier",

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TY - JOUR

T1 - Population-based head-to-head comparison of the clinical characteristics and epidemiology of AQP4 antibody-positive NMOSD between two European countries

AU - Viktoria, Papp

AU - Trones, Kim D P

AU - Magyari, Melinda

AU - Koch-Henriksen, Nils

AU - Iljicsov, Anna

AU - Rajda, Cecilia

AU - Nielsen, Helle H

AU - Lovas, Gabor

AU - Rozsa, Csilla

AU - Kristiansen, Bjørn H

AU - Stenager, Egon

AU - Frederiksen, Jette L

AU - Komoly, Samuel

AU - Sellebjerg, Finn

AU - Petersen, Thor

AU - Illes, Zsolt

PY - 2021/6

Y1 - 2021/6

N2 - BACKGROUND: Population-based clinical studies in neuromyelitis optica spectrum disorder (NMOSD) and epidemiological and clinical comparisons of White ethnicities are missing. In a large population-based international cohort, we extensively characterized aquaporin-4 antibody seropositive (AQP4-Ab+) NMOSD, and also compared the clinical, radiological and epidemiological features between two European populations residing in different areas.METHODS: Between self-reported Danish and Hungarian ethnicities, we compared the population-based clinical features, disability outcomes, and death of 134 AQP4-Ab+ NMOSD cases fulfilling the 2015 International Panel for NMO Diagnosis (IPND) criteria. For precise comparison of epidemiology, we conducted a population-based head-to-head comparative study of the age-standardized prevalence (January 1, 2014) and incidence (2007-2013) of AQP4-Ab+ NMO/NMOSD among adults (≥16 years) in Denmark (4.6 million) and Hungary (6.4 million) by applying 2015 IPND (NMOSD) criteria and 2006 Wingerchuk (NMO).RESULTS: Danes were more likely to present with transverse myelitis and were more affected by spinal cord damage on long-term disability. Hungarians presented most often with optic neuritis, although visual outcome was similar in the groups. No differences were observed in sex, disease course, relapse rate, autoimmune comorbidity, mortality, brain MRI, and treatment strategies. The age-standardized prevalence estimates of AQP4-Ab+ NMOSD (2015 IPND criteria) in Denmark vs. Hungary were 0.66 vs. 1.43 (/100,000) while incidence rates were 0.04 vs. 0.11 (/100,000 person-years); similar differences were found based on the 2006 NMO criteria.CONCLUSIONS: This head-to-head comparative study indicates different disease characteristics and epidemiology among White populations in Europe, and substantiates the need for population-based genetic and environmental studies in NMOSD.

AB - BACKGROUND: Population-based clinical studies in neuromyelitis optica spectrum disorder (NMOSD) and epidemiological and clinical comparisons of White ethnicities are missing. In a large population-based international cohort, we extensively characterized aquaporin-4 antibody seropositive (AQP4-Ab+) NMOSD, and also compared the clinical, radiological and epidemiological features between two European populations residing in different areas.METHODS: Between self-reported Danish and Hungarian ethnicities, we compared the population-based clinical features, disability outcomes, and death of 134 AQP4-Ab+ NMOSD cases fulfilling the 2015 International Panel for NMO Diagnosis (IPND) criteria. For precise comparison of epidemiology, we conducted a population-based head-to-head comparative study of the age-standardized prevalence (January 1, 2014) and incidence (2007-2013) of AQP4-Ab+ NMO/NMOSD among adults (≥16 years) in Denmark (4.6 million) and Hungary (6.4 million) by applying 2015 IPND (NMOSD) criteria and 2006 Wingerchuk (NMO).RESULTS: Danes were more likely to present with transverse myelitis and were more affected by spinal cord damage on long-term disability. Hungarians presented most often with optic neuritis, although visual outcome was similar in the groups. No differences were observed in sex, disease course, relapse rate, autoimmune comorbidity, mortality, brain MRI, and treatment strategies. The age-standardized prevalence estimates of AQP4-Ab+ NMOSD (2015 IPND criteria) in Denmark vs. Hungary were 0.66 vs. 1.43 (/100,000) while incidence rates were 0.04 vs. 0.11 (/100,000 person-years); similar differences were found based on the 2006 NMO criteria.CONCLUSIONS: This head-to-head comparative study indicates different disease characteristics and epidemiology among White populations in Europe, and substantiates the need for population-based genetic and environmental studies in NMOSD.

KW - Adolescent

KW - Adult

KW - Aquaporin 4

KW - Autoantibodies

KW - Denmark/epidemiology

KW - Europe/epidemiology

KW - Humans

KW - Hungary

KW - Neuromyelitis Optica/diagnostic imaging

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U2 - 10.1016/j.msard.2021.102879

DO - 10.1016/j.msard.2021.102879

M3 - Journal article

C2 - 33714126

VL - 51

SP - 102879

JO - Multiple Sclerosis and Related Disorders

JF - Multiple Sclerosis and Related Disorders

SN - 2211-0348

M1 - 102879

ER -

Population-based head-to-head comparison of the clinical characteristics and epidemiology of AQP4 antibody-positive NMOSD between two European countries

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