Polymorphonuclear leucocyte dysfunction during short term metabolic changes from normo- to hyperglycemia in type 1 (insulin dependent) diabetic patients

H Kjersem, J Hilsted, S Madsbad, Johan Wandall, K S Johansen, N Borregaard

72 Citations (Scopus)

Abstract

Polymorphonuclear leucocyte (PMN) ingestion of particles coated with lipopolysaccharide (LPS) from Escherichia coli was compared to other PMN functions in seven patients with insulin dependent diabetes mellitus (IDDM) during short-term controlled metabolic changes from normo- to hyperglycemia without ketoacidosis. Factors known to interfere with PMN functions were excluded. PMN ingestion of particles coated with both LPS and bovine serum albumin became reduced from normo- to hyperglycemia. PMN motility was impaired in IDDM, but did not seem to be affected by short-term changes in metabolic control. PMN metabolism did not change from normo-to hyperglycemia. Particle-uptake by diabetic PMN is impaired after short term hyperglycemia in the range normally occurring in diabetics in every-day life.
Original languageEnglish
JournalInfection
Volume16
Issue number4
Pages (from-to)215-21
Number of pages7
ISSN0300-8126
Publication statusPublished - 1988

Keywords

  • Adult
  • Blood Bactericidal Activity
  • Blood Glucose
  • Chemotaxis, Leukocyte
  • Diabetes Mellitus, Type 1
  • Escherichia coli
  • Humans
  • Hyperglycemia
  • Lipopolysaccharides
  • Male
  • Neutrophils
  • Phagocytosis
  • Superoxides

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