Polymorphisms of the peroxisome proliferator-activated receptor γ (PPARγ) gene are associated with osteoporosis

Torben Harsløf; C L Tofteng; Mette Nyegaard; Anders Børglum; Mette Carstens; Liselotte Stenkjær; Kim Torsten Brixen; P Eiken; Jens-Erik Beck Jensen; Leif Mosekilde; Lars Rejnmark; Bente Lomholt Langdahl; L.B. Husted

doi:10.1007/s00198-010-1491-z

Polymorphisms of the peroxisome proliferator-activated receptor γ (PPARγ) gene are associated with osteoporosis

Torben Harsløf, C L Tofteng, Mette Nyegaard, Anders Børglum, Mette Carstens, Liselotte Stenkjær, Kim Torsten Brixen, P Eiken, Jens-Erik Beck Jensen, Leif Mosekilde, Lars Rejnmark, Bente Lomholt Langdahl, L.B. Husted

Endocrinology Unit

19 Citations (Scopus)

Abstract

Stimulation of PPARγ turns mesenchymal stem cells into adipocytes instead of osteoblasts. We investigated the effect of polymorphisms in the PPARγ gene on BMD and fracture risk in two Danish cohorts and found opposing effects of certain SNPs and haplotypes in the two cohorts probably owing to environmental factors.

Original language	English
Journal	Osteoporosis International
Volume	22
Issue number	10
Pages (from-to)	2655-66
Number of pages	12
ISSN	0937-941X
DOIs	https://doi.org/10.1007/s00198-010-1491-z
Publication status	Published - 2011

Keywords

Adult
Aged
Body Weight
Bone Density
Case-Control Studies
Diet
Female
Haplotypes
Humans
Longitudinal Studies
Male
Middle Aged
Osteoporosis
Osteoporotic Fractures
PPAR gamma
Polymorphism, Single Nucleotide
Risk Factors
Spinal Fractures

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Harsløf, T., Tofteng, C. L., Nyegaard, M., Børglum, A., Carstens, M., Stenkjær, L., Brixen, K. T., Eiken, P., Jensen, J.-E. B., Mosekilde, L., Rejnmark, L., Langdahl, B. L., & Husted, L. B. (2011). Polymorphisms of the peroxisome proliferator-activated receptor γ (PPARγ) gene are associated with osteoporosis. Osteoporosis International, 22(10), 2655-66. https://doi.org/10.1007/s00198-010-1491-z

Harsløf, T, Tofteng, CL, Nyegaard, M, Børglum, A, Carstens, M, Stenkjær, L, Brixen, KT, Eiken, P , Jensen, J-EB, Mosekilde, L, Rejnmark, L, Langdahl, BL & Husted, LB 2011, 'Polymorphisms of the peroxisome proliferator-activated receptor γ (PPARγ) gene are associated with osteoporosis', Osteoporosis International, vol. 22, no. 10, pp. 2655-66. https://doi.org/10.1007/s00198-010-1491-z

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keywords = "Adult, Aged, Body Weight, Bone Density, Case-Control Studies, Diet, Female, Haplotypes, Humans, Longitudinal Studies, Male, Middle Aged, Osteoporosis, Osteoporotic Fractures, PPAR gamma, Polymorphism, Single Nucleotide, Risk Factors, Spinal Fractures",

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doi = "10.1007/s00198-010-1491-z",

language = "English",

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T1 - Polymorphisms of the peroxisome proliferator-activated receptor γ (PPARγ) gene are associated with osteoporosis

AU - Harsløf, Torben

AU - Tofteng, C L

AU - Nyegaard, Mette

AU - Børglum, Anders

AU - Carstens, Mette

AU - Stenkjær, Liselotte

AU - Brixen, Kim Torsten

AU - Eiken, P

AU - Jensen, Jens-Erik Beck

AU - Mosekilde, Leif

AU - Rejnmark, Lars

AU - Langdahl, Bente Lomholt

AU - Husted, L.B.

PY - 2011

Y1 - 2011

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AB - Stimulation of PPARγ turns mesenchymal stem cells into adipocytes instead of osteoblasts. We investigated the effect of polymorphisms in the PPARγ gene on BMD and fracture risk in two Danish cohorts and found opposing effects of certain SNPs and haplotypes in the two cohorts probably owing to environmental factors.

KW - Adult

KW - Aged

KW - Body Weight

KW - Bone Density

KW - Case-Control Studies

KW - Diet

KW - Female

KW - Haplotypes

KW - Humans

KW - Longitudinal Studies

KW - Male

KW - Middle Aged

KW - Osteoporosis

KW - Osteoporotic Fractures

KW - PPAR gamma

KW - Polymorphism, Single Nucleotide

KW - Risk Factors

KW - Spinal Fractures

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DO - 10.1007/s00198-010-1491-z

M3 - Journal article

C2 - 21104228

SN - 0937-941X

VL - 22

SP - 2655

EP - 2666

JO - Osteoporosis International

JF - Osteoporosis International

IS - 10

ER -

Polymorphisms of the peroxisome proliferator-activated receptor γ (PPARγ) gene are associated with osteoporosis

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Keywords

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