Polymorphisms in the MASP1 gene are associated with serum levels of MASP-1, MASP-3, and MAp44

Christian Gytz Ammitzbøll; Rudi Steffensen; Hans Jørgen Nielsen; Steffen Thiel; Kristian Stengaard-Pedersen; Martin Bøgsted; Jens Christian Jensenius

doi:10.1371/journal.pone.0073317

Polymorphisms in the MASP1 gene are associated with serum levels of MASP-1, MASP-3, and MAp44

Christian Gytz Ammitzbøll, Rudi Steffensen, Hans Jørgen Nielsen, Steffen Thiel, Kristian Stengaard-Pedersen, Martin Bøgsted, Jens Christian Jensenius

19 Citations (Scopus)

Abstract

MASP-1 is the first protein in the activation of the lectin pathway and MASP-1 is, like its isoforms MASP-3 and MAp44, encoded by the MASP1 gene. Our aim was to explore associations between polymorphisms in MASP1 and corresponding concentrations of MASP-1, MASP-3, and MAp44 in plasma as well as the genetic contribution to the equilibrium between the three proteins.

Original language	English
Journal	P L o S One
Volume	8
Issue number	9
Pages (from-to)	e73317
ISSN	1932-6203
DOIs	https://doi.org/10.1371/journal.pone.0073317
Publication status	Published - 2013

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10.1371/journal.pone.0073317

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abstract = "MASP-1 is the first protein in the activation of the lectin pathway and MASP-1 is, like its isoforms MASP-3 and MAp44, encoded by the MASP1 gene. Our aim was to explore associations between polymorphisms in MASP1 and corresponding concentrations of MASP-1, MASP-3, and MAp44 in plasma as well as the genetic contribution to the equilibrium between the three proteins.",

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AU - Gytz Ammitzbøll, Christian

AU - Steffensen, Rudi

AU - Jørgen Nielsen, Hans

AU - Thiel, Steffen

AU - Stengaard-Pedersen, Kristian

AU - Bøgsted, Martin

AU - Jensenius, Jens Christian

PY - 2013

Y1 - 2013

N2 - MASP-1 is the first protein in the activation of the lectin pathway and MASP-1 is, like its isoforms MASP-3 and MAp44, encoded by the MASP1 gene. Our aim was to explore associations between polymorphisms in MASP1 and corresponding concentrations of MASP-1, MASP-3, and MAp44 in plasma as well as the genetic contribution to the equilibrium between the three proteins.

AB - MASP-1 is the first protein in the activation of the lectin pathway and MASP-1 is, like its isoforms MASP-3 and MAp44, encoded by the MASP1 gene. Our aim was to explore associations between polymorphisms in MASP1 and corresponding concentrations of MASP-1, MASP-3, and MAp44 in plasma as well as the genetic contribution to the equilibrium between the three proteins.

UR - https://www.scopus.com/pages/publications/84897922049

U2 - 10.1371/journal.pone.0073317

DO - 10.1371/journal.pone.0073317

M3 - Journal article

C2 - 24023860

SN - 1932-6203

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SP - e73317

JO - P L o S One

JF - P L o S One

IS - 9

ER -

Polymorphisms in the MASP1 gene are associated with serum levels of MASP-1, MASP-3, and MAp44

Abstract

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