Research
Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital
Published

Polymorphisms in Genes Coding for Cytokines, Mannose-Binding Lectin, Collagen Metabolism and Thrombophilia in Women with Cervical Insufficiency

Research output: Contribution to journalJournal articleResearchpeer-review

DOI

  1. Placental Growth during Normal Pregnancy - A Magnetic Resonance Imaging Study

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Two Cases of True Uterine Artery Aneurysms Diagnosed during Pregnancy

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Follow-up interviews after eclampsia

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Multifactorial etiology of recurrent miscarriage and its scientific and clinical implications

    Research output: Contribution to journalJournal articleResearchpeer-review

  1. Thyroid peroxidase antibodies and prospective live birth rate: A cohort study of women with recurrent pregnancy loss

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Gestational diabetes is associated with change in the gut microbiota composition in third trimester of pregnancy and postpartum

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Recurrence rates after abdominal and vaginal cerclages in women with cervical insufficiency: a validated cohort study

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Gentagne Graviditetstab

    Research output: Contribution to journalJournal articleResearchpeer-review

View graph of relations

OBJECTIVE: To study the association between cervical insufficiency and single nucleotide polymorphisms in seven genes coding for pro- and anti-inflammatory cytokine-related factors, mannose-binding lectin 2 (MBL2), collagen1α1 (COL1A1), factor II and factor V Leiden genes.

METHODS: In a case-control study, potential maternal biomarkers for cervical insufficiency were investigated in 30 women with a history of second-trimester miscarriage or preterm birth due to cervical insufficiency and in 70 control women.

RESULTS: Homozygous carriers of the interleukin 6 (IL6) -174 genotype GG had an odds ratio (OR) of 3.1 [95% confidence interval (95% CI) 1.3-7.4, p = 0.01] and MBL2 genotypes coding for low or intermediate levels of plasma MBL had an OR of 3.3 (95% CI 1.2-9.0, p = 0.01) for cervical insufficiency compared with controls. Serum MBL levels were lower in women with cervical insufficiency than in controls (median 408 and 1,985 ng/ml, respectively, p < 0.01).

CONCLUSIONS: Single nucleotide polymorphisms in the IL6 gene and the MBL2 gene and low MBL levels related to the latter polymorphism may increase the risk of preterm birth due to cervical insufficiency.

Original languageEnglish
JournalGynecologic and Obstetric Investigation
Volume81
Issue number1
Pages (from-to)15-22
Number of pages8
ISSN0378-7346
DOIs
Publication statusPublished - 2016

ID: 46177972