Abstract
Advanced glycation end-products (AGEs) may play an important role in the pathogenesis and progression of cardiovascular and renal complications of diabetes. Four putative AGE receptors (RAGEs), AGE-R1, AGE-R2, and AGE-R3 have been described. In this study, we scanned the sequence of the genes encoding these AGE receptors in 48 patients with type 1 diabetes and investigated the identified polymorphisms (n = 19) in 199 type 1 diabetic patients with nephropathy and 193 type 1 diabetic patients without nephropathy. Overall, none of the polymorphisms was strongly associated with nephropathy. The minor allele of a polymorphism located in the promoter region of the RAGE gene (C-1152A) conferred a weak protective effect (P < 0.05) and was associated with a longer duration of nephropathy-free diabetes (P = 0.08).
| Original language | English |
|---|---|
| Journal | Diabetes |
| Volume | 50 |
| Issue number | 5 |
| Pages (from-to) | 1214-8 |
| Number of pages | 5 |
| ISSN | 0012-1797 |
| Publication status | Published - May 2001 |
Keywords
- 5' Untranslated Regions
- Adolescent
- Adult
- Advanced Glycosylation End Product-Specific Receptor
- Age of Onset
- Chromosome Mapping
- Chromosomes, Human, Pair 1
- Chromosomes, Human, Pair 14
- Chromosomes, Human, Pair 19
- Chromosomes, Human, Pair 6
- Diabetes Mellitus, Type 1
- Diabetic Nephropathies
- Genetic Testing
- Glycosylation End Products, Advanced
- Homozygote
- Humans
- Point Mutation
- Polymorphism, Genetic
- Promoter Regions, Genetic
- Protein Isoforms
- Receptors, Immunologic
- Comparative Study
- Journal Article
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