Research
Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital
Published

Polygenic predisposition to breast cancer and the risk of coronary artery disease

Research output: Contribution to journalJournal articleResearchpeer-review

  1. Women with coronary microvascular dysfunction and no obstructive coronary artery disease have reduced exercise capacity

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Mortality and morbidity of major congenital heart disease related to general prenatal screening for malformations

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. An echocardiographic substrate for dyspnea identifies high risk patients with type 2 diabetes

    Research output: Contribution to journalJournal articleResearchpeer-review

  1. Association between Type D personality and outcomes in patients with non-ischemic heart failure

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Phenome-wide association analysis of LDL-cholesterol lowering genetic variants in PCSK9

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. A More COMPLETE Picture of Revascularization in STEMI

    Research output: Contribution to journalJournal articleResearchpeer-review

View graph of relations

BACKGROUND: Whether the increased risk of coronary artery disease (CAD) in patients with breast cancer may be linked to shared genetics is unknown. Our objective was to investigate the association of genetic predisposition to breast cancer with CAD risk via 1) a polygenic risk score 2) a nationwide case-control study.

METHODS AND RESULTS: We studied the associations of a polygenic risk score based on 91 single nucleotide polymorphisms previously associated with breast cancer in genome-wide association studies with the risk of CAD in a sample of patients undergoing coronary angiography. Secondary outcomes were prevalent atrial fibrillation, heart failure and breast cancer. Logistic regression models were used to analyze the associations. The risk of CAD associated with having a mother with breast cancer was analyzed with conditional logistic regression in the case-control study. Among 4985 patients undergoing coronary angiography (median age 66 years (Quartile (Q) 1-Q3 57-73), 65% male) 3724 (75%) had CAD. Increasing polygenic risk score was not associated with risks of CAD (odds ratio (OR) 1.01, 95% confidence interval (CI) 0.94-1.08), atrial fibrillation (OR 1.03, CI 0.94-1.12), or heart failure (OR 0.97, CI 0.90-1.05). In women, increasing polygenic risk score was associated with the risk of breast cancer (OR 1.40, CI 1.14-1.73). The risk of CAD was not significantly increased in children with vs. without mothers with breast cancer (Hazard ratio 0.89 95% CI 0.83-0.96, p = 0.002).

CONCLUSIONS: Our study found no evidence of a shared genetic predisposition of breast cancer with CAD, atrial fibrillation, or heart failure.

Original languageEnglish
JournalInternational Journal of Cardiology
Volume291
Pages (from-to)145-151
Number of pages7
ISSN0167-5273
DOIs
Publication statusPublished - 15 Sep 2019

    Research areas

  • Atrial fibrillation, Breast cancer, Coronary artery disease, Genetic association studies, Heart failure

ID: 57284712