Research
Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital
Published

Point of no return for improvement of cartilage quality indicated by dGEMRIC before and after weight loss in patients with knee osteoarthritis: a cohort study

Research output: Contribution to journalJournal articleResearchpeer-review

DOI

  1. Grading lumbar disc degeneration: a comparison between low- and high-field MRI

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. The effects of rotation on radiological parameters in the spine

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. The efficacy of using computer-aided detection (CAD) for detection of breast cancer in mammography screening: a systematic review

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. New section editor: Cardiac Imaging

    Research output: Contribution to journalJournal articleCommunication

  1. Imaging of Common Rheumatic Joint Diseases Affecting the Upper Limbs

    Research output: Contribution to journalReviewResearchpeer-review

  2. Early occupational intervention for people with low back pain in physically demanding jobs: A randomized clinical trial

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Inflammation and Hypervascularization in a Large Animal Model of Knee Osteoarthritis: Imaging with Pathohistologic Correlation

    Research output: Contribution to journalJournal articleResearchpeer-review

View graph of relations

Background It has been demonstrated that weight loss improves symptoms in obese subjects with knee osteoarthritis (KOA). A parallel change in cartilage morphology remains to be demonstrated. Purpose To demonstrate a parallel change in cartilage morphology. Material and Methods Obese patients with KOA were examined before and after weight loss over 16 weeks. Target knee joints were radiographically assessed by the Kellgren/Lawrence grading (KLG) system. Patients with KLG-1 and 2 changes in the lateral compartment were included. Delayed gadolinium-enhanced MRI of cartilage (dGEMRIC) was performed using intra-articular contrast. Results Nine patients with lateral KLG-1 and ten patients with lateral KLG-2 were studied. There were no group differences regarding the lateral compartment baseline dGEMRIC T1 values: median = 497 ms (KLG-1) and 533 ms (KLG-2) ( P = 0.12), or regarding reduction in body mass index (BMI) after 16 weeks: 12.8% versus 11.4% ( P = 0.74). In the KLG-1 group, several cases of increased dGEMRIC T1 values were seen and median value decreased significantly less than in KLG-2 group (15 ms versus 41 ms, P = 0.03) after weight loss. Conclusion Improvement of cartilage quality, assessed with dGEMRIC, after weight loss might be possible in early stage KOA (KLG-1), but not in later stage KOA (KLG-2). The results may suggest a point of no return for improvement of cartilage quality that should be tested in larger trials.

Original languageEnglish
JournalActa Radiologica
Volume59
Issue number3
Pages (from-to)336-340
Number of pages5
ISSN0284-1851
DOIs
Publication statusPublished - Mar 2018

    Research areas

  • Aged, Cartilage, Articular, Cohort Studies, Contrast Media, Female, Follow-Up Studies, Humans, Image Enhancement, Knee Joint, Magnetic Resonance Imaging, Male, Meglumine, Middle Aged, Obesity, Organometallic Compounds, Osteoarthritis, Knee, Weight Loss, Journal Article

ID: 53652888