Pleiotropic effects of HNF1A rs1183910 in a population-based study of 60,283 individuals

Kristine H Allin; Børge G Nordestgaard

doi:10.1007/s00125-013-3156-x

Pleiotropic effects of HNF1A rs1183910 in a population-based study of 60,283 individuals

10 Citations (Scopus)

Abstract

According to genome-wide association studies (GWAS) a locus in the HNF1A gene has pleiotropic effects on several metabolic traits. In a large single-centre study we used the intronic variant rs1183910 located in a region with no or low recombination rate as an instrument for the HNF1A locus to evaluate pleiotropic effects of this locus on the risk of developing type 2 diabetes, as well as on body composition and levels of non-fasting glucose, lipids, acute-phase reactants, and biomarkers of liver and pancreas function.

Original language	English
Journal	Diabetologia
Volume	57
Issue number	4
Pages (from-to)	729-737
Number of pages	9
ISSN	0012-186X
DOIs	https://doi.org/10.1007/s00125-013-3156-x
Publication status	Published - 19 Jan 2014

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abstract = "According to genome-wide association studies (GWAS) a locus in the HNF1A gene has pleiotropic effects on several metabolic traits. In a large single-centre study we used the intronic variant rs1183910 located in a region with no or low recombination rate as an instrument for the HNF1A locus to evaluate pleiotropic effects of this locus on the risk of developing type 2 diabetes, as well as on body composition and levels of non-fasting glucose, lipids, acute-phase reactants, and biomarkers of liver and pancreas function.",

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AU - Nordestgaard, Børge G

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Y1 - 2014/1/19

N2 - According to genome-wide association studies (GWAS) a locus in the HNF1A gene has pleiotropic effects on several metabolic traits. In a large single-centre study we used the intronic variant rs1183910 located in a region with no or low recombination rate as an instrument for the HNF1A locus to evaluate pleiotropic effects of this locus on the risk of developing type 2 diabetes, as well as on body composition and levels of non-fasting glucose, lipids, acute-phase reactants, and biomarkers of liver and pancreas function.

AB - According to genome-wide association studies (GWAS) a locus in the HNF1A gene has pleiotropic effects on several metabolic traits. In a large single-centre study we used the intronic variant rs1183910 located in a region with no or low recombination rate as an instrument for the HNF1A locus to evaluate pleiotropic effects of this locus on the risk of developing type 2 diabetes, as well as on body composition and levels of non-fasting glucose, lipids, acute-phase reactants, and biomarkers of liver and pancreas function.

UR - https://www.scopus.com/pages/publications/84896101341

U2 - 10.1007/s00125-013-3156-x

DO - 10.1007/s00125-013-3156-x

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EP - 737

JO - Diabetologia

JF - Diabetologia

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ER -

Pleiotropic effects of HNF1A rs1183910 in a population-based study of 60,283 individuals

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