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The Capital Region of Denmark - a part of Copenhagen University Hospital
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Platelet function in lung cancer patients undergoing lobectomy

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  1. Circadian variations in plasma concentrations of cholecystokinin and gastrin in man

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  2. Validation of suPAR turbidimetric assay on Cobas® (c502 and c702) and comparison to suPAR ELISA

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  1. Effect of insulin on natriuretic peptide gene expression in porcine heart

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  2. Experimental non-alcoholic steatohepatitis in Göttingen Minipigs: consequences of high fat-fructose-cholesterol diet and diabetes

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  3. Cardiac procholecystokinin expression during haemodynamic changes in the mammalian heart

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  4. Monitoring variables affecting positron emission tomography measurements of cerebral blood flow in anaesthetized pigs

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  5. Coagulation profile in open and video-assisted thoracoscopic lobectomies: a cohort study

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A growing interest concerns arterial thromboembolic disease in cancer patients. As platelets may be key players in this process, investigation of platelet aggregation in cancer patients is of importance. We aimed to investigate platelet aggregation in patients with lung cancer prior to surgery and during video-assisted thoracoscopic surgery (VATS) lobectomy compared with lobectomy performed through a thoracotomy. We included 93 patients (VATS + low molecular weight heparin (LMWH), n = 32; VATS no LMWH, n = 31; thoracotomy + LMWH, n = 30). Data obtained from 121 healthy individuals were used for comparison prior to surgery. Platelet aggregation was analysed by impedance aggregometry using adenosine diphosphate 6.5 μM (ADPtest) and collagen 3.2 μg/mL (COLtest) as agonists. Prior to surgery, platelet aggregation was significantly increased in both VATS-patients (ADPtest, p < .0001; COLtest, p = .0002) and patients undergoing thoracotomy (ADPtest, p < .0001; COLtest, p < .0001) compared with healthy individuals. Platelet aggregation did not differ between VATS-patients and thoracotomy patients prior to surgery (p-values >.11). At the first postoperative day, VATS-patients demonstrated significantly higher collagen-induced platelet aggregation than preoperatively (p = .001), but the increase in platelet aggregation did not differ significantly between VATS and thoracotomy patients (p-values ≥.24). At the second postoperative day, platelet aggregation was significantly reduced in thoracotomy patients compared with the preoperative level (ADPtest, p = .002; COLtest, p = .05). In conclusion, platelet aggregation was significantly increased in patients with primary lung cancer prior to surgery compared with healthy individuals. At the first postoperative day, platelet aggregation was significantly higher than the preoperative level in VATS-patients; however, this increase did not differ between patient groups.

Original languageEnglish
JournalScandinavian Journal of Clinical and Laboratory Investigation
Volume79
Issue number7
Pages (from-to)513-518
Number of pages6
ISSN0036-5513
DOIs
Publication statusPublished - Nov 2019

    Research areas

  • haemostasis, lung cancer, neoplasm, Platelet aggregation, surgery

ID: 58306619