Platelet count kinetics following Interruption of antiretroviral treatment: Results from the SMART study

Eva Zetterberg; Jacqueline Neuhaus; Jason V Baker; Charurut Somboonwit; Josep M Llibre; Adrian Palfreeman; Maria Chini; Jens D Lundgren; for the INSIGHT SMART Study Group

doi:10.1097/QAD.0b013e32835a104d

Platelet count kinetics following Interruption of antiretroviral treatment: Results from the SMART study

Eva Zetterberg
, Jacqueline Neuhaus
, Jason V Baker
, Charurut Somboonwit
, Josep M Llibre
, Adrian Palfreeman
, Maria Chini
, Jens D Lundgren
, for the INSIGHT SMART Study Group

12 Citations (Scopus)

Abstract

OBJECTIVES:: To investigate the mechanisms of platelet kinetics in the SMART study that demonstrated excess mortality with CD4 guided episodic antiretroviral therapy (ART) (drug conservation [DC]) compared to continuous treatment (viral suppression [VS]). Follow up analyses of stored plasma samples demonstrated increased activation of both inflammatory and coagulation pathways after stopping ART. DESIGN:: SMART patients from sites that determined platelets routinely. METHODS:: Platelet counts were retrospectively collected from 2206 patients from visits at study entry, and during follow-up. D-dimer levels were measured at study entry, month 1, and 2. RESULTS:: Platelet levels decreased in the DC group following randomization, but remained stable in the VS group [median (IQR) decline from study entry to month 4: -24,000/μL(-54,000-4,000) vs. 3000 (-22,000-24,000), respectively, p

Original language	English
Journal	AIDS
Volume	27
Issue number	1
Pages (from-to)	59-68
ISSN	0269-9370
DOIs	https://doi.org/10.1097/QAD.0b013e32835a104d
Publication status	Published - 2013

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10.1097/QAD.0b013e32835a104d

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title = "Platelet count kinetics following Interruption of antiretroviral treatment: Results from the SMART study",

abstract = "OBJECTIVES:: To investigate the mechanisms of platelet kinetics in the SMART study that demonstrated excess mortality with CD4 guided episodic antiretroviral therapy (ART) (drug conservation [DC]) compared to continuous treatment (viral suppression [VS]). Follow up analyses of stored plasma samples demonstrated increased activation of both inflammatory and coagulation pathways after stopping ART. DESIGN:: SMART patients from sites that determined platelets routinely. METHODS:: Platelet counts were retrospectively collected from 2206 patients from visits at study entry, and during follow-up. D-dimer levels were measured at study entry, month 1, and 2. RESULTS:: Platelet levels decreased in the DC group following randomization, but remained stable in the VS group [median (IQR) decline from study entry to month 4: -24,000/μL(-54,000-4,000) vs. 3000 (-22,000-24,000), respectively, p ",

author = "Eva Zetterberg and Jacqueline Neuhaus and Baker, \{Jason V\} and Charurut Somboonwit and Llibre, \{Josep M\} and Adrian Palfreeman and Maria Chini and Lundgren, \{Jens D\} and \{for the INSIGHT SMART Study Group\}",

year = "2013",

doi = "10.1097/QAD.0b013e32835a104d",

language = "English",

volume = "27",

pages = "59--68",

journal = "AIDS",

issn = "0269-9370",

publisher = "Lippincott Williams and Wilkins",

number = "1",

}

TY - JOUR

T1 - Platelet count kinetics following Interruption of antiretroviral treatment

T2 - Results from the SMART study

AU - Zetterberg, Eva

AU - Neuhaus, Jacqueline

AU - Baker, Jason V

AU - Somboonwit, Charurut

AU - Llibre, Josep M

AU - Palfreeman, Adrian

AU - Chini, Maria

AU - Lundgren, Jens D

AU - for the INSIGHT SMART Study Group

PY - 2013

Y1 - 2013

N2 - OBJECTIVES:: To investigate the mechanisms of platelet kinetics in the SMART study that demonstrated excess mortality with CD4 guided episodic antiretroviral therapy (ART) (drug conservation [DC]) compared to continuous treatment (viral suppression [VS]). Follow up analyses of stored plasma samples demonstrated increased activation of both inflammatory and coagulation pathways after stopping ART. DESIGN:: SMART patients from sites that determined platelets routinely. METHODS:: Platelet counts were retrospectively collected from 2206 patients from visits at study entry, and during follow-up. D-dimer levels were measured at study entry, month 1, and 2. RESULTS:: Platelet levels decreased in the DC group following randomization, but remained stable in the VS group [median (IQR) decline from study entry to month 4: -24,000/μL(-54,000-4,000) vs. 3000 (-22,000-24,000), respectively, p

AB - OBJECTIVES:: To investigate the mechanisms of platelet kinetics in the SMART study that demonstrated excess mortality with CD4 guided episodic antiretroviral therapy (ART) (drug conservation [DC]) compared to continuous treatment (viral suppression [VS]). Follow up analyses of stored plasma samples demonstrated increased activation of both inflammatory and coagulation pathways after stopping ART. DESIGN:: SMART patients from sites that determined platelets routinely. METHODS:: Platelet counts were retrospectively collected from 2206 patients from visits at study entry, and during follow-up. D-dimer levels were measured at study entry, month 1, and 2. RESULTS:: Platelet levels decreased in the DC group following randomization, but remained stable in the VS group [median (IQR) decline from study entry to month 4: -24,000/μL(-54,000-4,000) vs. 3000 (-22,000-24,000), respectively, p

U2 - 10.1097/QAD.0b013e32835a104d

DO - 10.1097/QAD.0b013e32835a104d

M3 - Journal article

C2 - 23018440

SN - 0269-9370

VL - 27

SP - 59

EP - 68

JO - AIDS

JF - AIDS

IS - 1

ER -

Platelet count kinetics following Interruption of antiretroviral treatment: Results from the SMART study

Abstract

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