Platelet activation and dysfunction in a large-animal model of traumatic brain injury and hemorrhage

Martin Sillesen; Pär I Johansson; Lars S Rasmussen; Guang Jin; Cecilie H Jepsen; Ayehsa M Imam; John Hwabejire; Jennifer Lu; Michael Duggan; George Velmahos; Marc deMoya; Hasan B Alam

doi:10.1097/TA.0b013e31828c7a6b

Platelet activation and dysfunction in a large-animal model of traumatic brain injury and hemorrhage

Martin Sillesen, Pär I Johansson, Lars S Rasmussen, Guang Jin, Cecilie H Jepsen, Ayehsa M Imam, John Hwabejire, Jennifer Lu, Michael Duggan, George Velmahos, Marc deMoya, Hasan B Alam

68 Citations (Scopus)

Abstract

Traumatic brain injury (TBI) and hemorrhage are the leading causes of trauma-related mortality. Both TBI and hemorrhage are associated with coagulation disturbances, including platelet dysfunction. We hypothesized that platelet dysfunction could be detected early after injury, and that this dysfunction would be associated with early activation, as measured by circulating levels of platelet activation markers.

Original language	English
Journal	The journal of trauma and acute care surgery
Volume	74
Issue number	5
Pages (from-to)	1252-9
Number of pages	8
DOIs	https://doi.org/10.1097/TA.0b013e31828c7a6b
Publication status	Published - May 2013

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Sillesen, M., Johansson, P. I., Rasmussen, L. S., Jin, G., Jepsen, C. H., Imam, A. M., Hwabejire, J., Lu, J., Duggan, M., Velmahos, G., deMoya, M., & Alam, H. B. (2013). Platelet activation and dysfunction in a large-animal model of traumatic brain injury and hemorrhage. The journal of trauma and acute care surgery, 74(5), 1252-9. https://doi.org/10.1097/TA.0b013e31828c7a6b

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abstract = "Traumatic brain injury (TBI) and hemorrhage are the leading causes of trauma-related mortality. Both TBI and hemorrhage are associated with coagulation disturbances, including platelet dysfunction. We hypothesized that platelet dysfunction could be detected early after injury, and that this dysfunction would be associated with early activation, as measured by circulating levels of platelet activation markers.",

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AU - Sillesen, Martin

AU - Johansson, Pär I

AU - Rasmussen, Lars S

AU - Jin, Guang

AU - Jepsen, Cecilie H

AU - Imam, Ayehsa M

AU - Hwabejire, John

AU - Lu, Jennifer

AU - Duggan, Michael

AU - Velmahos, George

AU - deMoya, Marc

AU - Alam, Hasan B

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N2 - Traumatic brain injury (TBI) and hemorrhage are the leading causes of trauma-related mortality. Both TBI and hemorrhage are associated with coagulation disturbances, including platelet dysfunction. We hypothesized that platelet dysfunction could be detected early after injury, and that this dysfunction would be associated with early activation, as measured by circulating levels of platelet activation markers.

AB - Traumatic brain injury (TBI) and hemorrhage are the leading causes of trauma-related mortality. Both TBI and hemorrhage are associated with coagulation disturbances, including platelet dysfunction. We hypothesized that platelet dysfunction could be detected early after injury, and that this dysfunction would be associated with early activation, as measured by circulating levels of platelet activation markers.

UR - https://www.scopus.com/pages/publications/84877057201

U2 - 10.1097/TA.0b013e31828c7a6b

DO - 10.1097/TA.0b013e31828c7a6b

M3 - Journal article

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EP - 1259

JO - The journal of trauma and acute care surgery

JF - The journal of trauma and acute care surgery

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ER -

Platelet activation and dysfunction in a large-animal model of traumatic brain injury and hemorrhage

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