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The Capital Region of Denmark - a part of Copenhagen University Hospital
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Plasma volume changes during hypoglycaemia: the effect of arterial blood sampling.

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To investigate whether previously reported changes in venous blood volume and composition induced by acute hypoglycaemia in humans are representative for the entire body we measured erythrocyte 51Cr content, haematocrit, plasma volume, intravascular albumin content and transcapillary escape rate of albumin in arterial and venous blood in seven healthy subjects before and during insulin-induced hypoglycaemia. In both vascular sites blood 51Cr content and the haematocrit increased, plasma volume and intravascular albumin content decreased and the transcapillary escape rate of albumin increased during hypoglycaemia. The magnitude of the changes in arterial and venous blood were not significantly different. These results indicate that the above changes in blood volume and composition are whole-body phenomena: furthermore, the major part of the changes are likely to occur in tissues other than upper extremity muscles.
Translated title of the contributionPlasma volume changes during hypoglycaemia: the effect of arterial blood sampling.
Original languageEnglish
JournalScandinavian Journal of Clinical & Laboratory Investigation
Volume50
Issue number7
Pages (from-to)797-800
Number of pages4
ISSN0036-5513
Publication statusPublished - 1990

ID: 32561512