Research
Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital
Published

Plasma urate, lung function and chronic obstructive pulmonary disease: a Mendelian randomisation study in 114 979 individuals from the general population

Research output: Contribution to journalJournal articleResearchpeer-review

  1. One-year outcomes in a multicentre cohort study of incident rare diffuse parenchymal lung disease in children (ChILD)

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. β2-Adrenergic genotypes and risk of severe exacerbations in COPD: a prospective cohort study

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Midlife cardiorespiratory fitness and the long-term risk of chronic obstructive pulmonary disease

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Impact of cystic fibrosis on birthweight: a population based study of children in Denmark and Wales

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Geographical variations in the use of cancer treatments are associated with survival of lung cancer patients

    Research output: Contribution to journalJournal articleResearchpeer-review

  1. Tocilizumab and soluble interleukin-6 receptor in JAK2V617F somatic mutation and myeloproliferative neoplasm

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Impact of Glucose Level on Micro- and Macrovascular Disease in the General Population: A Mendelian Randomization Study

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Two-fold risk of pneumonia and respiratory mortality in individuals with myeloproliferative neoplasm: A population-based cohort study

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Eligibility and Preventive Potential for New Evidence-Based Cardiovascular Drugs in Secondary Prevention

    Research output: Contribution to journalReviewResearchpeer-review

View graph of relations

BACKGROUND: Urate is a strong antioxidant in plasma and may protect against lung function impairment. We tested the hypothesis that high plasma urate is causally associated with better lung function and low risk of respiratory symptoms and COPD.

METHODS: We measured lung function and plasma urate in 114 979 individuals from the Copenhagen City Heart Study and the Copenhagen General Population Study and genotyped for SLC2A9 rs7442295 and ABCG2 rs2231142 variants, previously associated with high plasma urate, in 110 152 individuals.

RESULTS: In the two studies combined, multivariable-adjusted 100 µmol/L higher plasma urate was associated with -1.54% (95% CI -1.67 to -1.40) lower FEV1 % predicted and -1.57% (95% CI -1.69 to -1.44) lower FVC % predicted observationally; the corresponding estimates for genetically determined 100 µmol/L higher plasma urate were -0.46% (95% CI -1.17 to 0.25) and -0.40% (95% CI -1.03 to 0.23). High plasma urate was also associated with higher risk of respiratory symptoms; however, genetically determined high plasma urate was not associated with respiratory symptoms. Finally, we identified 14 151 individuals with COPD and found ORs of 1.08 (95% CI 1.06 to 1.11) for COPD observationally and 1.01 (95% CI 0.88 to 1.15) genetically per 100 µmol/L higher plasma urate.

CONCLUSION: High plasma urate was associated with worse lung function and higher risk of respiratory symptoms and COPD in observational analyses; however, genetically high plasma urate was not associated with any of these outcomes. Thus, our data do not support a direct causal relationship.

Original languageEnglish
JournalThorax
Volume73
Issue number8
Pages (from-to)748-757
Number of pages10
ISSN0040-6376
DOIs
Publication statusPublished - Aug 2018

    Research areas

  • Aged, Biomarkers/blood, Denmark, Female, Genetic Variation, Genotype, Humans, Male, Middle Aged, Predictive Value of Tests, Pulmonary Disease, Chronic Obstructive/blood, Respiratory Function Tests, Risk Factors, Uric Acid/blood

ID: 56616549