Research
Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital
Published

Plasma levels of mannose-binding lectin and future risk of venous thromboembolism

Research output: Contribution to journalJournal articleResearchpeer-review

DOI

  1. Reply to: Clinical impact of high platelet count and high hematocrit, by Marc Sorigue

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Good practice statements (GPS) for the clinical care of patients with thrombotic thrombocytopenic purpura

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. ISTH guidelines for the diagnosis of thrombotic thrombocytopenic purpura

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. ISTH guidelines for treatment of thrombotic thrombocytopenic purpura

    Research output: Contribution to journalJournal articleResearchpeer-review

  1. Shiga Toxin 2a Binds to Complement Components C3b and C5 and Upregulates Their Gene Expression in Human Cell Lines

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Lectin complement pathway initiators after subarachnoid hemorrhage - an observational study

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Soluble collectin-12 mediates C3-independent docking of properdin that activates the alternative pathway of complement

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Local complement activation is associated with primary graft dysfunction after lung transplantation

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Complement Activation and Thrombin Generation by MBL Bound to β2-Glycoprotein I

    Research output: Contribution to journalJournal articleResearchpeer-review

  • Robin A Liang
  • Ina I Høiland
  • Thor Ueland
  • Pål Aukrust
  • Omri Snir
  • Kristian Hindberg
  • Sigrid K Braekkan
  • Peter Garred
  • Tom E Mollnes
  • John-Bjarne Hansen
View graph of relations

BACKGROUND: Animal and observational studies have suggested a pathophysiological role for complement in venous thromboembolism (VTE), but the initiating mechanisms are unknown. Mannose-binding lectin (MBL) bound to altered host cells leads to activation of the lectin complement pathway, and both high and low MBL levels have been implicated in the pathophysiology of cardiovascular disease.

OBJECTIVES: To investigate the association between plasma MBL levels and future risk of incident VTE.

METHODS: We conducted a nested case-control study in 417 VTE patients and 849 age-matched and sex-matched controls derived from the general population (Tromsø Study). Plasma MBL levels were measured using enzyme-linked immunosorbent assay. Logistic regression models were used to estimate odds ratio (OR) for VTE across quartiles of plasma MBL levels.

RESULTS: Subjects with plasma MBL levels in the lowest quartile (<435 ng/mL) had a reduced OR for overall VTE (OR 0.79, 95% confidence interval [CI]: 0.56-1.10) and for DVT (OR 0.70, 95% CI: 0.47-1.04) compared to those with MBL in the highest quartile (≥2423 ng/mL) after multivariable adjustments. For VTE, DVT, and pulmonary embolism (PE) the ORs decreased substantially with decreasing time between blood sampling and VTE event.

CONCLUSIONS: Our findings suggest that low plasma MBL levels are associated with reduced risk of VTE, and DVT in particular.

Original languageEnglish
JournalJournal of thrombosis and haemostasis : JTH
Pages (from-to)1661-1669
Number of pages9
ISSN1538-7933
DOIs
Publication statusPublished - 20 Jun 2019

ID: 58007864