Plasma lactate responses during and after submaximal handgrip exercise are not diagnostically helpful in mitochondrial myopathy

Nicoline Løkken; Sofie Vinther Skriver; Tahmina Khawajazada; Jesper Helbo Storgaard; John Vissing

doi:10.1016/j.mito.2021.07.002

Plasma lactate responses during and after submaximal handgrip exercise are not diagnostically helpful in mitochondrial myopathy

Nicoline Løkken, Sofie Vinther Skriver, Tahmina Khawajazada, Jesper Helbo Storgaard, John Vissing

Department of Neurology

Abstract

INTRODUCTION/BACKGROUND: Mitochondrial myopathy (MM) encompasses a clinical heterogenous group of patients that can be difficult to diagnose. The aim of this study was to investigate if changes in plasma lactate concentration during a 6-minute submaximal handgrip test (6MHGT) and a 20-minute post-exercise recovery period can be used as a diagnostic test for MM.

METHODS: Twenty-nine patients with MM and nineteen healthy controls (HC) performed an intermittent handgrip exercise test at ½ Hz for 6 min at 50% of maximal voluntary contraction force. We calculated the area under the curve (AUC) of change in plasma lactate during exercise and recovery and compared AUC between groups (MM vs. HC, and between MM subgroups based on disease severity).

RESULTS: The change in plasma lactate during exercise and recovery was similar in MM and HC (p = 0.65 and p = 0.57) and similar between MM subgroups (p ≥ 0.24).

CONCLUSION: Plasma lactate measured during and after a submaximal 6MHGT cannot be used as a diagnostic variable for MM.

Original language	English
Journal	Mitochondrion
Volume	60
Pages (from-to)	21-26
Number of pages	6
ISSN	1567-7249
DOIs	https://doi.org/10.1016/j.mito.2021.07.002
Publication status	Published - Sept 2021

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10.1016/j.mito.2021.07.002

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@article{debadb5fa5664373b3789b44f9159759,

title = "Plasma lactate responses during and after submaximal handgrip exercise are not diagnostically helpful in mitochondrial myopathy",

abstract = "INTRODUCTION/BACKGROUND: Mitochondrial myopathy (MM) encompasses a clinical heterogenous group of patients that can be difficult to diagnose. The aim of this study was to investigate if changes in plasma lactate concentration during a 6-minute submaximal handgrip test (6MHGT) and a 20-minute post-exercise recovery period can be used as a diagnostic test for MM.METHODS: Twenty-nine patients with MM and nineteen healthy controls (HC) performed an intermittent handgrip exercise test at ½ Hz for 6 min at 50% of maximal voluntary contraction force. We calculated the area under the curve (AUC) of change in plasma lactate during exercise and recovery and compared AUC between groups (MM vs. HC, and between MM subgroups based on disease severity).RESULTS: The change in plasma lactate during exercise and recovery was similar in MM and HC (p = 0.65 and p = 0.57) and similar between MM subgroups (p ≥ 0.24).CONCLUSION: Plasma lactate measured during and after a submaximal 6MHGT cannot be used as a diagnostic variable for MM.",

author = "Nicoline L{\o}kken and Skriver, {Sofie Vinther} and Tahmina Khawajazada and Storgaard, {Jesper Helbo} and John Vissing",

year = "2021",

month = sep,

doi = "10.1016/j.mito.2021.07.002",

language = "English",

volume = "60",

pages = "21--26",

journal = "Mitochondrion",

issn = "1567-7249",

publisher = "Elsevier BV",

}

TY - JOUR

T1 - Plasma lactate responses during and after submaximal handgrip exercise are not diagnostically helpful in mitochondrial myopathy

AU - Løkken, Nicoline

AU - Skriver, Sofie Vinther

AU - Khawajazada, Tahmina

AU - Storgaard, Jesper Helbo

AU - Vissing, John

PY - 2021/9

Y1 - 2021/9

N2 - INTRODUCTION/BACKGROUND: Mitochondrial myopathy (MM) encompasses a clinical heterogenous group of patients that can be difficult to diagnose. The aim of this study was to investigate if changes in plasma lactate concentration during a 6-minute submaximal handgrip test (6MHGT) and a 20-minute post-exercise recovery period can be used as a diagnostic test for MM.METHODS: Twenty-nine patients with MM and nineteen healthy controls (HC) performed an intermittent handgrip exercise test at ½ Hz for 6 min at 50% of maximal voluntary contraction force. We calculated the area under the curve (AUC) of change in plasma lactate during exercise and recovery and compared AUC between groups (MM vs. HC, and between MM subgroups based on disease severity).RESULTS: The change in plasma lactate during exercise and recovery was similar in MM and HC (p = 0.65 and p = 0.57) and similar between MM subgroups (p ≥ 0.24).CONCLUSION: Plasma lactate measured during and after a submaximal 6MHGT cannot be used as a diagnostic variable for MM.

AB - INTRODUCTION/BACKGROUND: Mitochondrial myopathy (MM) encompasses a clinical heterogenous group of patients that can be difficult to diagnose. The aim of this study was to investigate if changes in plasma lactate concentration during a 6-minute submaximal handgrip test (6MHGT) and a 20-minute post-exercise recovery period can be used as a diagnostic test for MM.METHODS: Twenty-nine patients with MM and nineteen healthy controls (HC) performed an intermittent handgrip exercise test at ½ Hz for 6 min at 50% of maximal voluntary contraction force. We calculated the area under the curve (AUC) of change in plasma lactate during exercise and recovery and compared AUC between groups (MM vs. HC, and between MM subgroups based on disease severity).RESULTS: The change in plasma lactate during exercise and recovery was similar in MM and HC (p = 0.65 and p = 0.57) and similar between MM subgroups (p ≥ 0.24).CONCLUSION: Plasma lactate measured during and after a submaximal 6MHGT cannot be used as a diagnostic variable for MM.

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U2 - 10.1016/j.mito.2021.07.002

DO - 10.1016/j.mito.2021.07.002

M3 - Journal article

C2 - 34273558

SN - 1567-7249

VL - 60

SP - 21

EP - 26

JO - Mitochondrion

JF - Mitochondrion

ER -

Plasma lactate responses during and after submaximal handgrip exercise are not diagnostically helpful in mitochondrial myopathy

Abstract

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