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Plasma insulin-like growth factor I as predictor of progression and all cause mortality in chronic heart failure

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  1. Lower levels of placental growth hormone in early pregnancy in women with type 1 diabetes and large for gestational age infants

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  2. Insulin-like growth factor I enhances collagen synthesis in engineered human tendon tissue

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  3. Positive associations between serum levels of IGF-I and subcutaneous fat depots in young men. The Odense Androgen Study

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  4. The insulin like growth factor system in cirrhosis. Relation to changes in body composition following adrenoreceptor blockade

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OBJECTIVES: Insulin-like growth factor I (IGF-I) is an anabolic growth factor that seems to increase cardiac contractility. Reduced levels of IGF-I may be implicated in progression of CHF. The objective was to compare plasma IGF-I in CHF patients with healthy controls, and to examine the associations between baseline IGF-I levels, cardiac contractility and the prognosis as judged by all cause mortality and progression of CHF requiring admission to hospital. METHODS: A prospective study comprising 194 CHF outpatients, and 169 matched controls. All patients and controls underwent echocardiographic examination at baseline. Patients were followed for a median of 30 months. RESULTS: There was no difference in IGF-I levels between patients and controls (median and interquartile range), 78 (58-91) vs. 77 (57-94)ng/mL (P=0.92). Age-adjusted IGF-I levels were not related to left ventricular ejection fraction (LVEF) (P=0.58) or levels of N-terminal B-Type natriuretic peptide (NT-proBNP) (P=0.42). During follow-up 44 patients died and 94 were admitted to hospital due to worsening of CHF. Adjusted for cardiovascular risk factors (age, gender, NT-proBNP, lipids, diabetes mellitus, blood pressure, renal function and LVEF) IGF-I levels did not influence the overall mortality risk or the admission rate to hospital, hazard ratio (HR) (95% confidence intervals) 1.05 (0.75-1.47) (P=0.77) and 1.00 (0.80-1.26) (P=0.96), respectively per each SD increase in log IGF-I levels. CONCLUSIONS: IGF-I levels were not reduced in patients with CHF and did not influence cardiac status at baseline or the prognosis.
Original languageEnglish
JournalGrowth Hormone & IGF Research
Volume19
Issue number6
Pages (from-to)486-90
Number of pages4
ISSN1096-6374
DOIs
Publication statusPublished - 2009

Bibliographical note

Keywords: Aged; Case-Control Studies; Chronic Disease; Disease Progression; Female; Heart Failure; Humans; Insulin-Like Growth Factor I; Male; Middle Aged; Myocardial Contraction; Prospective Studies; Risk Factors; Time Factors; Treatment Outcome

ID: 172099