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Plasma ficolin levels and risk of nephritis in Danish patients with systemic lupus erythematosus

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@article{5120da652aab4cceb2fa5b99ab8e523b,
title = "Plasma ficolin levels and risk of nephritis in Danish patients with systemic lupus erythematosus",
abstract = "Given the scavenging properties of ficolins, we hypothesized that variation in the plasma concentrations of the three ficolins may be associated with development of lupus nephritis (LN), type of LN, end-stage renal disease (ESRD), and/or mortality among patients with systemic lupus erythematosus (SLE). SLE patients attending a Danish tertiary rheumatology referral center were included. Plasma concentrations of ficolin-1, ficolin-2, and ficolin-3 were determined and dichotomized by the median into high and low. LN was defined by clinical criteria; type of LN by renal biopsy; ESRD follow-up time was defined as time from onset of LN to the development of ESRD or censoring at the end of follow-up. The study included 112 SLE patients with median disease duration of 8 years of which 53 (47{\%}) had LN at the time of inclusion. During a median follow-up of 10 years, five patients developed ESRD. Sixteen patients died. Odds ratios (ORs) of LN were 1.2 (95{\%} CI: 0.6-2.7), 4.1 (95{\%} CI: 1.7-9.7), and 0.9 (95{\%} CI: 0.4-2.0) for patients with low ficolin-1, ficolin-2, and ficolin-3 plasma levels, respectively. The distribution of histological classes differed between patients with high and low plasma levels of ficolin-1 (p = 0.009). Patients with high ficolin-1 plasma levels had an increased risk of ESRD. There was no association between the levels of the analyzed plasma ficolins and mortality. Low plasma ficolin-2 levels were associated with an increased risk of having LN. High plasma levels of ficolin-1 were associated with the histological subtype of LN and development of ESRD.",
keywords = "Adult, Aged, Biopsy, Denmark, Female, Follow-Up Studies, Glycoproteins, Humans, Immunity, Innate, Kidney Failure, Chronic, Lectins, Lupus Erythematosus, Systemic, Male, Middle Aged, Nephritis, Risk, Treatment Outcome, Young Adult, Journal Article",
author = "Nima Tanha and Katrine Pilely and Mikkel Faurschou and Peter Garred and S{\o}ren Jacobsen",
year = "2017",
month = "2",
doi = "10.1007/s10067-016-3508-2",
language = "English",
volume = "36",
pages = "335--341",
journal = "Clinical Rheumatology",
issn = "0770-3198",
publisher = "Springer U K",
number = "2",

}

RIS

TY - JOUR

T1 - Plasma ficolin levels and risk of nephritis in Danish patients with systemic lupus erythematosus

AU - Tanha, Nima

AU - Pilely, Katrine

AU - Faurschou, Mikkel

AU - Garred, Peter

AU - Jacobsen, Søren

PY - 2017/2

Y1 - 2017/2

N2 - Given the scavenging properties of ficolins, we hypothesized that variation in the plasma concentrations of the three ficolins may be associated with development of lupus nephritis (LN), type of LN, end-stage renal disease (ESRD), and/or mortality among patients with systemic lupus erythematosus (SLE). SLE patients attending a Danish tertiary rheumatology referral center were included. Plasma concentrations of ficolin-1, ficolin-2, and ficolin-3 were determined and dichotomized by the median into high and low. LN was defined by clinical criteria; type of LN by renal biopsy; ESRD follow-up time was defined as time from onset of LN to the development of ESRD or censoring at the end of follow-up. The study included 112 SLE patients with median disease duration of 8 years of which 53 (47%) had LN at the time of inclusion. During a median follow-up of 10 years, five patients developed ESRD. Sixteen patients died. Odds ratios (ORs) of LN were 1.2 (95% CI: 0.6-2.7), 4.1 (95% CI: 1.7-9.7), and 0.9 (95% CI: 0.4-2.0) for patients with low ficolin-1, ficolin-2, and ficolin-3 plasma levels, respectively. The distribution of histological classes differed between patients with high and low plasma levels of ficolin-1 (p = 0.009). Patients with high ficolin-1 plasma levels had an increased risk of ESRD. There was no association between the levels of the analyzed plasma ficolins and mortality. Low plasma ficolin-2 levels were associated with an increased risk of having LN. High plasma levels of ficolin-1 were associated with the histological subtype of LN and development of ESRD.

AB - Given the scavenging properties of ficolins, we hypothesized that variation in the plasma concentrations of the three ficolins may be associated with development of lupus nephritis (LN), type of LN, end-stage renal disease (ESRD), and/or mortality among patients with systemic lupus erythematosus (SLE). SLE patients attending a Danish tertiary rheumatology referral center were included. Plasma concentrations of ficolin-1, ficolin-2, and ficolin-3 were determined and dichotomized by the median into high and low. LN was defined by clinical criteria; type of LN by renal biopsy; ESRD follow-up time was defined as time from onset of LN to the development of ESRD or censoring at the end of follow-up. The study included 112 SLE patients with median disease duration of 8 years of which 53 (47%) had LN at the time of inclusion. During a median follow-up of 10 years, five patients developed ESRD. Sixteen patients died. Odds ratios (ORs) of LN were 1.2 (95% CI: 0.6-2.7), 4.1 (95% CI: 1.7-9.7), and 0.9 (95% CI: 0.4-2.0) for patients with low ficolin-1, ficolin-2, and ficolin-3 plasma levels, respectively. The distribution of histological classes differed between patients with high and low plasma levels of ficolin-1 (p = 0.009). Patients with high ficolin-1 plasma levels had an increased risk of ESRD. There was no association between the levels of the analyzed plasma ficolins and mortality. Low plasma ficolin-2 levels were associated with an increased risk of having LN. High plasma levels of ficolin-1 were associated with the histological subtype of LN and development of ESRD.

KW - Adult

KW - Aged

KW - Biopsy

KW - Denmark

KW - Female

KW - Follow-Up Studies

KW - Glycoproteins

KW - Humans

KW - Immunity, Innate

KW - Kidney Failure, Chronic

KW - Lectins

KW - Lupus Erythematosus, Systemic

KW - Male

KW - Middle Aged

KW - Nephritis

KW - Risk

KW - Treatment Outcome

KW - Young Adult

KW - Journal Article

U2 - 10.1007/s10067-016-3508-2

DO - 10.1007/s10067-016-3508-2

M3 - Journal article

VL - 36

SP - 335

EP - 341

JO - Clinical Rheumatology

JF - Clinical Rheumatology

SN - 0770-3198

IS - 2

ER -

ID: 52002857