Plasma exchange in antineutrophil cytoplasmic antibody-associated vasculitis--a 25-year perspective

    18 Citations (Scopus)

    Abstract

    Demonstration of a pathogenic role for antineutrophil cytoplasmic antibodies (ANCA) underlies the scientific rationale for plasma exchange (PLEX) in the treatment of ANCA-associated vasculitis (AAV). Most clinical evidence of efficacy concerns the use of PLEX for the recovery of renal function in severe nephritis, when used in conjunction with immunosuppressive drug therapy. The development of PLEX for this indication, the strength of the clinical trial evidence supporting its use, its roles in other AAV indications and ongoing research are discussed.

    Original languageEnglish
    JournalNephrology, Dialysis, Transplantation
    Volume30 Suppl 1
    Pages (from-to)i146-9
    ISSN0931-0509
    DOIs
    Publication statusPublished - Apr 2015

    Keywords

    • Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis
    • Humans
    • Immunosuppressive Agents
    • Plasma Exchange

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