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The Capital Region of Denmark - a part of Copenhagen University Hospital
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Plasma cytokine profiles at diagnosis in pediatric patients with non-hodgkin lymphoma

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  1. Acute liver failure in a four-year old girl during maintenance therapy of acute lymphoblastic leukemia

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  2. Gene dose effects of GSTM1, GSTT1 and GSTP1 polymorphisms on outcome in childhood acute lymphoblastic leukemia

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  3. Duration of adrenal insufficiency during treatment for childhood acute lymphoblastic leukemia

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  1. Asparaginase Enzyme Activity Levels and Toxicity in Childhood Acute Lymphoblastic Leukemia: a NOPHO ALL2008 study

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  2. DNA-thioguanine concentration and relapse risk in children and young adults with acute lymphoblastic leukemia: an IPD meta-analysis

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  3. Pancreatitis-associated protein as an early marker of asparaginase-associated pancreatitis

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Non-Hodgkin lymphoma (NHL) has been associated with elevated levels of inflammatory and immune-regulating cytokines, and polymorphisms in the genes encoding interleukin (IL)-10 and tumor necrosis factor (TNF)-α have been associated with increased incidence of certain subtypes of NHL. The aim of the present study was to screen for a broader spectrum of growth factors and inflammatory mediators and to compare the profiles in different subtypes of NHL in pediatric patients. Serum samples were collected at diagnosis from 31 pediatric patients diagnosed with NHL admitted at Rigshospitalet, Copenhagen, between 1995 and 2008. Cytokines and growth factors were measured in serum using the Luminex platform by application of a 30-plex kit. Levels of IL-6, IL-2R, IL-10, TNF-RI, and macrophage inflammatory protein-1α were significantly higher in patients with anaplastic large-cell lymphoma compared with patients diagnosed with B-cell lymphomas and lymphoblastic lymphomas. High levels of IL-4, IL-13, TNF-RI, and epidermal growth factor were associated with a poorer general condition at diagnosis. The present study suggests that NHL subgrouping and the general condition of pediatric patients at diagnosis are associated with plasma levels of growth factors and inflammatory mediators at presentation.
Original languageEnglish
JournalPediatric Hematology & Oncology
Volume34
Issue number4
Pages (from-to)271-5
Number of pages5
ISSN0888-0018
DOIs
Publication statusPublished - 2012

    Research areas

  • Adolescent, Child, Child, Preschool, Cytokines, Female, Humans, Infant, Lymphoma, Non-Hodgkin, Male, Receptors, Tumor Necrosis Factor, Type I, Retrospective Studies

ID: 36784765