Plasma and muscle myostatin in relation to type 2 diabetes

Claus Brandt; Anders R Nielsen; Christian P Fischer; Jakob Hansen; Bente K Pedersen; Peter Plomgaard

doi:10.1371/journal.pone.0037236

Plasma and muscle myostatin in relation to type 2 diabetes

Claus Brandt, Anders R Nielsen, Christian P Fischer, Jakob Hansen, Bente K Pedersen, Peter Plomgaard

84 Citations (Scopus)

Abstract

Myostatin is a secreted growth factor expressed in skeletal muscle tissue, which negatively regulates skeletal muscle mass. Recent animal studies suggest a role for myostatin in insulin resistance. We evaluated the possible metabolic role of myostatin in patients with type 2 diabetes and healthy controls.

Original language	English
Journal	P L o S One
Volume	7
Issue number	5
Pages (from-to)	e37236
ISSN	1932-6203
DOIs	https://doi.org/10.1371/journal.pone.0037236
Publication status	Published - 2012

Keywords

Diabetes Mellitus, Type 2
Female
Humans
Insulin
Insulin Resistance
Male
Middle Aged
Muscles
Myostatin
RNA, Messenger

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10.1371/journal.pone.0037236

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title = "Plasma and muscle myostatin in relation to type 2 diabetes",

abstract = "Myostatin is a secreted growth factor expressed in skeletal muscle tissue, which negatively regulates skeletal muscle mass. Recent animal studies suggest a role for myostatin in insulin resistance. We evaluated the possible metabolic role of myostatin in patients with type 2 diabetes and healthy controls.",

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AU - Brandt, Claus

AU - Nielsen, Anders R

AU - Fischer, Christian P

AU - Hansen, Jakob

AU - Pedersen, Bente K

AU - Plomgaard, Peter

PY - 2012

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KW - Diabetes Mellitus, Type 2

KW - Female

KW - Humans

KW - Insulin

KW - Insulin Resistance

KW - Male

KW - Middle Aged

KW - Muscles

KW - Myostatin

KW - RNA, Messenger

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DO - 10.1371/journal.pone.0037236

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JO - P L o S One

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Plasma and muscle myostatin in relation to type 2 diabetes

Abstract

Keywords

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