Research
Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital
Published

Plakoglobin: a diagnostic marker of arrhythmogenic right ventricular cardiomyopathy in forensic pathology?

Research output: Contribution to journalJournal articleResearchpeer-review

  1. Post-mortem MRI-based volumetry of the hippocampus in forensic cases of decedents with severe mental illness

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Skin and respiratory disorders following the identification of disaster victims in Thailand

    Research output: Contribution to journalJournal articleResearchpeer-review

  1. Rare non-coding Desmoglein-2 variant contributes to Arrhythmogenic right ventricular cardiomyopathy

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Cytomegalovirus Viral Load in Bronchoalveolar Lavage to Diagnose Lung Transplant Associated CMV Pneumonia

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Characterization of genetic intratumor heterogeneity in colorectal cancer and matching patient-derived spheroid cultures

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Fibrin thrombi in deceased donor kidneys: Prevalence and influence on graft function and graft survival in transplanted patients

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Pulmonary venous remodeling in COPD-pulmonary hypertension and idiopathic pulmonary arterial hypertension

    Research output: Contribution to journalJournal articleResearchpeer-review

View graph of relations

PURPOSE: The histopathological diagnosis of arrhythmogenic right ventricular cardiomyopathy (ARVC) can be challenging in forensic medicine. Immunohistochemical myocardial analysis for plakoglobin has been suggested as a new diagnostic test for ARVC. We examined this in the setting of forensic pathology, applying this method to forensic autopsy samples.

METHODS: We performed immunohistochemical staining for plakoglobin on 40 myocardial samples with an autopsy diagnosis of ARVC. In addition, histopathological reevaluation was performed applying the revised 2010 task force criteria including morphometric analysis. Myocardial samples from 15 subjects without heart disease were used as controls.

RESULTS: Based on the histopathological reevaluation, 38 out of 40 cases were categorized as ARVC. A marked reduction in the plakoglobin staining was seen in 26 out of 38 myocardial samples in the ARVC-group. Of the two samples categorized as not ARVC, one showed reduced plakoglobin staining and one sample had normal staining. No control samples showed reduced plakoglobin staining.

CONCLUSIONS: In conclusion, our study displayed reduced plakoglobin staining in approximately 2/3 of myocardial samples with ARVC. Our data suggests that immunostaining for plakoglobin might serve as an additional diagnostic marker of ARVC in forensic pathology, but additional validation is required.

Original languageEnglish
JournalForensic Science, Medicine, and Pathology
Volume11
Issue number1
Pages (from-to)47-52
Number of pages6
ISSN1547-769X
DOIs
Publication statusPublished - Mar 2015

    Research areas

  • Adolescent, Adult, Arrhythmogenic Right Ventricular Dysplasia, Autopsy, Biomarkers, Cause of Death, Child, Desmoplakins, Down-Regulation, Female, Forensic Pathology, Humans, Immunohistochemistry, Male, Middle Aged, Myocardium, Observer Variation, Predictive Value of Tests, Reproducibility of Results, Retrospective Studies, Young Adult

ID: 46023713