Placebo-controlled trial of amantadine for severe traumatic brain injury

Joseph T Giacino; John Whyte; Emilia Bagiella; Kathleen Kalmar; Nancy Childs; Allen Khademi; Bernd Eifert; David Long; Douglas I Katz; Sooja Cho; Stuart A Yablon; Marianne Luther; Flora M Hammond; Annette Nordenbo; Paul Novak; Walt Mercer; Petra Maurer-Karattup; Mark Sherer

doi:10.1056/NEJMoa1102609

Placebo-controlled trial of amantadine for severe traumatic brain injury

Joseph T Giacino, John Whyte, Emilia Bagiella, Kathleen Kalmar, Nancy Childs, Allen Khademi, Bernd Eifert, David Long, Douglas I Katz, Sooja Cho, Stuart A Yablon, Marianne Luther, Flora M Hammond, Annette Nordenbo, Paul Novak, Walt Mercer, Petra Maurer-Karattup, Mark Sherer

639 Citations (Scopus)

Abstract

Amantadine hydrochloride is one of the most commonly prescribed medications for patients with prolonged disorders of consciousness after traumatic brain injury. Preliminary studies have suggested that amantadine may promote functional recovery.

Original language	English
Journal	New England Journal of Medicine
Volume	366
Issue number	9
Pages (from-to)	819-26
Number of pages	8
ISSN	0028-4793
DOIs	https://doi.org/10.1056/NEJMoa1102609
Publication status	Published - 2012

Keywords

Adult
Amantadine
Brain Injuries
Coma, Post-Head Injury
Disability Evaluation
Dopamine Agents
Female
Glasgow Coma Scale
Humans
Male
Persistent Vegetative State
Recovery of Function

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10.1056/NEJMoa1102609

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Giacino, J. T., Whyte, J., Bagiella, E., Kalmar, K., Childs, N., Khademi, A., Eifert, B., Long, D., Katz, D. I., Cho, S., Yablon, S. A., Luther, M., Hammond, F. M., Nordenbo, A., Novak, P., Mercer, W., Maurer-Karattup, P., & Sherer, M. (2012). Placebo-controlled trial of amantadine for severe traumatic brain injury. New England Journal of Medicine, 366(9), 819-26. https://doi.org/10.1056/NEJMoa1102609

Giacino, JT, Whyte, J, Bagiella, E, Kalmar, K, Childs, N, Khademi, A, Eifert, B, Long, D, Katz, DI, Cho, S, Yablon, SA, Luther, M, Hammond, FM, Nordenbo, A, Novak, P, Mercer, W, Maurer-Karattup, P & Sherer, M 2012, 'Placebo-controlled trial of amantadine for severe traumatic brain injury', New England Journal of Medicine, vol. 366, no. 9, pp. 819-26. https://doi.org/10.1056/NEJMoa1102609

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abstract = "Amantadine hydrochloride is one of the most commonly prescribed medications for patients with prolonged disorders of consciousness after traumatic brain injury. Preliminary studies have suggested that amantadine may promote functional recovery.",

keywords = "Adult, Amantadine, Brain Injuries, Coma, Post-Head Injury, Disability Evaluation, Dopamine Agents, Female, Glasgow Coma Scale, Humans, Male, Persistent Vegetative State, Recovery of Function",

author = "Giacino, {Joseph T} and John Whyte and Emilia Bagiella and Kathleen Kalmar and Nancy Childs and Allen Khademi and Bernd Eifert and David Long and Katz, {Douglas I} and Sooja Cho and Yablon, {Stuart A} and Marianne Luther and Hammond, {Flora M} and Annette Nordenbo and Paul Novak and Walt Mercer and Petra Maurer-Karattup and Mark Sherer",

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AU - Giacino, Joseph T

AU - Whyte, John

AU - Bagiella, Emilia

AU - Kalmar, Kathleen

AU - Childs, Nancy

AU - Khademi, Allen

AU - Eifert, Bernd

AU - Long, David

AU - Katz, Douglas I

AU - Cho, Sooja

AU - Yablon, Stuart A

AU - Luther, Marianne

AU - Hammond, Flora M

AU - Nordenbo, Annette

AU - Novak, Paul

AU - Mercer, Walt

AU - Maurer-Karattup, Petra

AU - Sherer, Mark

PY - 2012

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KW - Adult

KW - Amantadine

KW - Brain Injuries

KW - Coma, Post-Head Injury

KW - Disability Evaluation

KW - Dopamine Agents

KW - Female

KW - Glasgow Coma Scale

KW - Humans

KW - Male

KW - Persistent Vegetative State

KW - Recovery of Function

U2 - 10.1056/NEJMoa1102609

DO - 10.1056/NEJMoa1102609

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EP - 826

JO - New England Journal of Medicine

JF - New England Journal of Medicine

IS - 9

ER -

Placebo-controlled trial of amantadine for severe traumatic brain injury

Abstract

Keywords

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