TY - JOUR
T1 - Pituitary gland volume in patients with schizophrenia, subjects at ultra high-risk of developing psychosis and healthy controls
T2 - a systematic review and meta-analysis
AU - Nordholm, Dorte
AU - Krogh, Jesper
AU - Mondelli, Valeria
AU - Dazzan, Paola
AU - Pariante, Carmine
AU - Nordentoft, Merete
N1 - Copyright © 2013 Elsevier Ltd. All rights reserved.
PY - 2013/11
Y1 - 2013/11
N2 - A larger pituitary size is thought to reflect a greater activation of the hypothalamic-pituitary-adrenal (HPA) axis, which may be related to an increase in the number and size of corticotroph cells. Some studies, but not all, indicate that pituitary volume increases before or at the onset of psychosis. There is a need for at critical appraisal of the literature on this topic accompanied by a meta-analytical evaluation of the data.
AB - A larger pituitary size is thought to reflect a greater activation of the hypothalamic-pituitary-adrenal (HPA) axis, which may be related to an increase in the number and size of corticotroph cells. Some studies, but not all, indicate that pituitary volume increases before or at the onset of psychosis. There is a need for at critical appraisal of the literature on this topic accompanied by a meta-analytical evaluation of the data.
U2 - 10.1016/j.psyneuen.2013.06.030
DO - 10.1016/j.psyneuen.2013.06.030
M3 - Journal article
C2 - 23890984
VL - 38
SP - 2394
EP - 2404
JO - Psychoneuroendocrinology
JF - Psychoneuroendocrinology
SN - 0306-4530
IS - 11
ER -