Pituitary gastrins occur in corticotrophs and melanotrophs

L I Larsson; J F Rehfeld

doi:10.1126/science.6266012

Pituitary gastrins occur in corticotrophs and melanotrophs

65 Citations (Scopus)

Abstract

The gut hormone gastrin was identified in pituitary cells containing adrenocorticotropic hormone and alpha-melanocyte--stimulating hormone by region-specific immunocytochemistry and radioimmunoassay. Smaller amounts of gastrin were found in nerve fibers of the neural lobe and pituitary stalk. Since adrenocorticotropic hormone--like peptides occur in antropyloric gastrin cells, these data indicate a considerable similarity in peptide composition of pituitary and gastrointestinal endocrine cells and reinforces questions of multiple hormone production.

Original language	English
Journal	Science
Volume	213
Issue number	4509
Pages (from-to)	768-70
Number of pages	3
ISSN	0036-8075
DOIs	https://doi.org/10.1126/science.6266012
Publication status	Published - 14 Aug 1981
Externally published	Yes

Keywords

Adrenocorticotropic Hormone/metabolism
Amino Acid Sequence
Animals
Cats
Gastrins/genetics
Histocytochemistry
Melanocyte-Stimulating Hormones/metabolism
Pituitary Gland/cytology
Radioimmunoassay
Swine

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10.1126/science.6266012

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title = "Pituitary gastrins occur in corticotrophs and melanotrophs",

abstract = "The gut hormone gastrin was identified in pituitary cells containing adrenocorticotropic hormone and alpha-melanocyte--stimulating hormone by region-specific immunocytochemistry and radioimmunoassay. Smaller amounts of gastrin were found in nerve fibers of the neural lobe and pituitary stalk. Since adrenocorticotropic hormone--like peptides occur in antropyloric gastrin cells, these data indicate a considerable similarity in peptide composition of pituitary and gastrointestinal endocrine cells and reinforces questions of multiple hormone production.",

keywords = "Adrenocorticotropic Hormone/metabolism, Amino Acid Sequence, Animals, Cats, Gastrins/genetics, Histocytochemistry, Melanocyte-Stimulating Hormones/metabolism, Pituitary Gland/cytology, Radioimmunoassay, Swine",

author = "Larsson, {L I} and Rehfeld, {J F}",

year = "1981",

month = aug,

day = "14",

doi = "10.1126/science.6266012",

language = "English",

volume = "213",

pages = "768--70",

journal = "Science",

issn = "0036-8075",

publisher = "American Association for the Advancement of Science",

number = "4509",

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TY - JOUR

T1 - Pituitary gastrins occur in corticotrophs and melanotrophs

AU - Larsson, L I

AU - Rehfeld, J F

PY - 1981/8/14

Y1 - 1981/8/14

N2 - The gut hormone gastrin was identified in pituitary cells containing adrenocorticotropic hormone and alpha-melanocyte--stimulating hormone by region-specific immunocytochemistry and radioimmunoassay. Smaller amounts of gastrin were found in nerve fibers of the neural lobe and pituitary stalk. Since adrenocorticotropic hormone--like peptides occur in antropyloric gastrin cells, these data indicate a considerable similarity in peptide composition of pituitary and gastrointestinal endocrine cells and reinforces questions of multiple hormone production.

AB - The gut hormone gastrin was identified in pituitary cells containing adrenocorticotropic hormone and alpha-melanocyte--stimulating hormone by region-specific immunocytochemistry and radioimmunoassay. Smaller amounts of gastrin were found in nerve fibers of the neural lobe and pituitary stalk. Since adrenocorticotropic hormone--like peptides occur in antropyloric gastrin cells, these data indicate a considerable similarity in peptide composition of pituitary and gastrointestinal endocrine cells and reinforces questions of multiple hormone production.

KW - Adrenocorticotropic Hormone/metabolism

KW - Amino Acid Sequence

KW - Animals

KW - Cats

KW - Gastrins/genetics

KW - Histocytochemistry

KW - Melanocyte-Stimulating Hormones/metabolism

KW - Pituitary Gland/cytology

KW - Radioimmunoassay

KW - Swine

U2 - 10.1126/science.6266012

DO - 10.1126/science.6266012

M3 - Journal article

C2 - 6266012

SN - 0036-8075

VL - 213

SP - 768

EP - 770

JO - Science

JF - Science

IS - 4509

ER -

Pituitary gastrins occur in corticotrophs and melanotrophs

Abstract

Keywords

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