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Physiology of female sexual function: animal models

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Harvard

Giraldi, A, Marson, L, Nappi, R, Pfaus, J, Traish, AM, Vardi, Y & Goldstein, I 2004, 'Physiology of female sexual function: animal models', The journal of sexual medicine, vol. 1, no. 3, pp. 237-53. https://doi.org/10.1111/j.1743-6109.04037.x

APA

Giraldi, A., Marson, L., Nappi, R., Pfaus, J., Traish, A. M., Vardi, Y., & Goldstein, I. (2004). Physiology of female sexual function: animal models. The journal of sexual medicine, 1(3), 237-53. https://doi.org/10.1111/j.1743-6109.04037.x

CBE

MLA

Vancouver

Author

Giraldi, Annamaria ; Marson, Lesley ; Nappi, Rossella ; Pfaus, James ; Traish, Abdulmaged M ; Vardi, Yoram ; Goldstein, Irwin. / Physiology of female sexual function : animal models. In: The journal of sexual medicine. 2004 ; Vol. 1, No. 3. pp. 237-53.

Bibtex

@article{255f3d7ec8114c08926694c3ba8ac249,
title = "Physiology of female sexual function: animal models",
abstract = "INTRODUCTION: Data concerning the physiology of desire, arousal, and orgasm in women are limited because of ethical constraints. Aim. To gain knowledge of physiology of female sexual function through animal models.METHODS: To provide state-of-the-art knowledge concerning female sexual function in animal models, representing the opinions of seven experts from five countries developed in a consensus process over a 2-year period.MAIN OUTCOME MEASURE: Expert opinion was based on the grading of evidence-based medical literature, widespread internal committee discussion, public presentation, and debate.RESULTS: Sexual desire may be considered as the presence of desire for, and fantasy about, sexual activity. Desire in animals can be inferred from certain appetitive behaviors that occur during copulation and from certain unconditioned copulatory measures. Proceptive behaviors are dependent in part on estrogen, progesterone, and drugs that bind to D1 dopamine receptors, adrenergic receptors, oxytocin receptors, opioid receptors, or gamma-amino butyric acid receptors. Peripheral arousal states are dependent on regulation of genital smooth muscle tone. Multiple neurotransmitters/mediators are involved including adrenergic, and nonadrenergic, noncholinergic agents such as vasoactive intestinal polypeptide, nitric oxide, neuropeptide Y, calcitonin gene-related peptide, and substance P. Sex steroid hormones, estrogens and androgens, are critical for structure and function of genital tissues including modulation of genital blood flow, lubrication, neurotransmitter function, smooth muscle contractility, mucification, and sex steroid receptor expression in genital tissues. Orgasm may be investigated by urethrogenital (UG) reflex, in which genital stimulation results in rhythmic contractions of striated perineal muscles and contractions of vagina, anus, and uterine smooth muscle. The UG reflex is generated by a multisegmental spinal pattern generator involving the coordination of sympathetic, parasympathetic, and somatic efferents innervating the genital organs. Serotonin and dopamine may modulate UG reflex activity.CONCLUSIONS: More research is needed in animal models in the physiology of female sexual function.",
keywords = "Anal Canal/physiology, Androgens/physiology, Animals, Appetitive Behavior/physiology, Behavior, Animal/physiology, Female, Genitalia/blood supply, Hemodynamics/physiology, Muscle Contraction/physiology, Muscle, Smooth/physiology, Neural Pathways/physiology, Neurotransmitter Agents/physiology, Orgasm/physiology, Sexual Behavior, Animal/physiology, Vagina/physiology",
author = "Annamaria Giraldi and Lesley Marson and Rossella Nappi and James Pfaus and Traish, {Abdulmaged M} and Yoram Vardi and Irwin Goldstein",
year = "2004",
month = nov,
doi = "10.1111/j.1743-6109.04037.x",
language = "English",
volume = "1",
pages = "237--53",
journal = "Journal of Sexual Medicine",
issn = "1743-6095",
publisher = "Wiley-Blackwell Publishing Ltd",
number = "3",

}

RIS

TY - JOUR

T1 - Physiology of female sexual function

T2 - animal models

AU - Giraldi, Annamaria

AU - Marson, Lesley

AU - Nappi, Rossella

AU - Pfaus, James

AU - Traish, Abdulmaged M

AU - Vardi, Yoram

AU - Goldstein, Irwin

PY - 2004/11

Y1 - 2004/11

N2 - INTRODUCTION: Data concerning the physiology of desire, arousal, and orgasm in women are limited because of ethical constraints. Aim. To gain knowledge of physiology of female sexual function through animal models.METHODS: To provide state-of-the-art knowledge concerning female sexual function in animal models, representing the opinions of seven experts from five countries developed in a consensus process over a 2-year period.MAIN OUTCOME MEASURE: Expert opinion was based on the grading of evidence-based medical literature, widespread internal committee discussion, public presentation, and debate.RESULTS: Sexual desire may be considered as the presence of desire for, and fantasy about, sexual activity. Desire in animals can be inferred from certain appetitive behaviors that occur during copulation and from certain unconditioned copulatory measures. Proceptive behaviors are dependent in part on estrogen, progesterone, and drugs that bind to D1 dopamine receptors, adrenergic receptors, oxytocin receptors, opioid receptors, or gamma-amino butyric acid receptors. Peripheral arousal states are dependent on regulation of genital smooth muscle tone. Multiple neurotransmitters/mediators are involved including adrenergic, and nonadrenergic, noncholinergic agents such as vasoactive intestinal polypeptide, nitric oxide, neuropeptide Y, calcitonin gene-related peptide, and substance P. Sex steroid hormones, estrogens and androgens, are critical for structure and function of genital tissues including modulation of genital blood flow, lubrication, neurotransmitter function, smooth muscle contractility, mucification, and sex steroid receptor expression in genital tissues. Orgasm may be investigated by urethrogenital (UG) reflex, in which genital stimulation results in rhythmic contractions of striated perineal muscles and contractions of vagina, anus, and uterine smooth muscle. The UG reflex is generated by a multisegmental spinal pattern generator involving the coordination of sympathetic, parasympathetic, and somatic efferents innervating the genital organs. Serotonin and dopamine may modulate UG reflex activity.CONCLUSIONS: More research is needed in animal models in the physiology of female sexual function.

AB - INTRODUCTION: Data concerning the physiology of desire, arousal, and orgasm in women are limited because of ethical constraints. Aim. To gain knowledge of physiology of female sexual function through animal models.METHODS: To provide state-of-the-art knowledge concerning female sexual function in animal models, representing the opinions of seven experts from five countries developed in a consensus process over a 2-year period.MAIN OUTCOME MEASURE: Expert opinion was based on the grading of evidence-based medical literature, widespread internal committee discussion, public presentation, and debate.RESULTS: Sexual desire may be considered as the presence of desire for, and fantasy about, sexual activity. Desire in animals can be inferred from certain appetitive behaviors that occur during copulation and from certain unconditioned copulatory measures. Proceptive behaviors are dependent in part on estrogen, progesterone, and drugs that bind to D1 dopamine receptors, adrenergic receptors, oxytocin receptors, opioid receptors, or gamma-amino butyric acid receptors. Peripheral arousal states are dependent on regulation of genital smooth muscle tone. Multiple neurotransmitters/mediators are involved including adrenergic, and nonadrenergic, noncholinergic agents such as vasoactive intestinal polypeptide, nitric oxide, neuropeptide Y, calcitonin gene-related peptide, and substance P. Sex steroid hormones, estrogens and androgens, are critical for structure and function of genital tissues including modulation of genital blood flow, lubrication, neurotransmitter function, smooth muscle contractility, mucification, and sex steroid receptor expression in genital tissues. Orgasm may be investigated by urethrogenital (UG) reflex, in which genital stimulation results in rhythmic contractions of striated perineal muscles and contractions of vagina, anus, and uterine smooth muscle. The UG reflex is generated by a multisegmental spinal pattern generator involving the coordination of sympathetic, parasympathetic, and somatic efferents innervating the genital organs. Serotonin and dopamine may modulate UG reflex activity.CONCLUSIONS: More research is needed in animal models in the physiology of female sexual function.

KW - Anal Canal/physiology

KW - Androgens/physiology

KW - Animals

KW - Appetitive Behavior/physiology

KW - Behavior, Animal/physiology

KW - Female

KW - Genitalia/blood supply

KW - Hemodynamics/physiology

KW - Muscle Contraction/physiology

KW - Muscle, Smooth/physiology

KW - Neural Pathways/physiology

KW - Neurotransmitter Agents/physiology

KW - Orgasm/physiology

KW - Sexual Behavior, Animal/physiology

KW - Vagina/physiology

U2 - 10.1111/j.1743-6109.04037.x

DO - 10.1111/j.1743-6109.04037.x

M3 - Review

C2 - 16422954

VL - 1

SP - 237

EP - 253

JO - Journal of Sexual Medicine

JF - Journal of Sexual Medicine

SN - 1743-6095

IS - 3

ER -

ID: 55814625