Research
Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital
Published

Physiological predictors of weight regain at 1-year follow-up in weight-reduced adults with obesity

Research output: Contribution to journalJournal articleResearchpeer-review

DOI

  1. BMI and Labor Market Participation: A Cohort Study of Transitions Between Work, Unemployment, and Sickness Absence

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Overweight Patterns Between Childhood and Early Adulthood and Esophageal and Gastric Cardia Adenocarcinoma Risk

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Body Composition Growth Patterns in Early Infancy: A Latent Class Trajectory Analysis of the Ethiopian iABC Birth Cohort

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Prospective studies exploring the possible impact of an ID3 polymorphism on changes in obesity measures

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Macrophage Area Content and Phenotype in Hepatic and Adipose Tissue in Patients with Obesity Undergoing Roux-en-Y Gastric Bypass

    Research output: Contribution to journalJournal articleResearchpeer-review

  1. Gastric cancer and gastrin: on the interaction of Helicobacter pylori gastritis and acid inhibitory induced hypergastrinemia

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Investigating the effect of sex and ketosis on weight-loss-induced changes in appetite

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Fructose malabsorption induces cholecystokinin expression in the ileum and cecum by changing microbiota composition and metabolism

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Opinion: Stop gaming peer review

    Research output: Contribution to journalComment/debateCommunication

  • Siren Nymo
  • Silvia R Coutinho
  • Jens F Rehfeld
  • Helen Truby
  • Bård Kulseng
  • Catia Martins
View graph of relations

OBJECTIVE: This study aimed to assess whether changes in resting metabolic rate (RMR), exercise-induced energy expenditure (EIEE), and appetite following weight loss (WL) are associated with weight regain at 1 year.

METHODS: Thirty-six adults with obesity underwent 8 weeks of a very-low-energy diet, followed by 4 weeks of refeeding and a 1-year maintenance program. RMR, EIEE, appetite ratings, and active ghrelin, peptide YY, glucagon-like peptide-1, cholecystokinin, and insulin concentrations were measured at baseline, week 13, and 1 year.

RESULTS: A 17% WL (-20 ± 5 kg [mean ± SD]; range: -11.7 to -32.2 kg; P < 0.001) was achieved at week 13. After 1 year, weight regain was 2.5 ± 9.0 kg (not significant), ranging from -18.2 to 22.5 kg. Both fat mass and fat-free mass were reduced at week 13 (-17.9 ± 4.8 and -2.9 ± 2.7 kg, respectively; P < 0.001), while only loss of fat mass was sustained at 1 year. WL was associated with reduced RMR, EIEE, and fasting/postprandial insulin (all P < 0.001), as well as increased fasting hunger (P < 0.01) and fasting/postprandial active ghrelin (P < 0.001). There were no significant correlations between changes in RMR, EIEE, or appetite with WL and weight regain at 1 year.

CONCLUSIONS: No clear evidence emerged that changes in RMR, EIEE, or appetite following WL can predict weight regain at 1 year, but larger studies are needed to confirm these results.

Original languageEnglish
JournalObesity (Silver Spring, Md.)
Volume27
Issue number6
Pages (from-to)925-931
Number of pages7
ISSN1930-7381
DOIs
Publication statusPublished - Jun 2019

ID: 57230980