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Physical fitness in community-dwelling older adults is linked to dietary intake, gut microbiota, and metabolomic signatures

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Harvard

Castro-Mejía, JL, Khakimov, B, Krych, L, Bülow, J, Bechshoeft, R, Højfeldt, GW, Mertz, KH, Garne, ES, Schacht, SR, Bin Ahmad, HF, Kot, WP, Hansen, LH, Perez-Cueto Eulert, FJA, Lind, MV, Juul Lassen, A, Tetens, I, Jensen, T, Reitelseder, S, Jespersen, AP, Holm, L, Engelsen, SB & Nielsen, DS 2020, 'Physical fitness in community-dwelling older adults is linked to dietary intake, gut microbiota, and metabolomic signatures', Aging Cell.

APA

Castro-Mejía, J. L., Khakimov, B., Krych, L., Bülow, J., Bechshoeft, R., Højfeldt, G. W., Mertz, K. H., Garne, E. S., Schacht, S. R., Bin Ahmad, H. F., Kot, W. P., Hansen, L. H., Perez-Cueto Eulert, F. J. A., Lind, M. V., Juul Lassen, A., Tetens, I., Jensen, T., Reitelseder, S., Jespersen, A. P., ... Nielsen, D. S. (2020). Physical fitness in community-dwelling older adults is linked to dietary intake, gut microbiota, and metabolomic signatures. Aging Cell.

CBE

Castro-Mejía JL, Khakimov B, Krych L, Bülow J, Bechshoeft R, Højfeldt GW, Mertz KH, Garne ES, Schacht SR, Bin Ahmad HF, Kot WP, Hansen LH, Perez-Cueto Eulert FJA, Lind MV, Juul Lassen A, Tetens I, Jensen T, Reitelseder S, Jespersen AP, Holm L, Engelsen SB, Nielsen DS. 2020. Physical fitness in community-dwelling older adults is linked to dietary intake, gut microbiota, and metabolomic signatures. Aging Cell.

MLA

Vancouver

Author

Castro-Mejía, Josué Leonardo ; Khakimov, Bekzod ; Krych, Lukasz ; Bülow, Jacob ; Bechshoeft, Rasmus ; Højfeldt, Grith Westergaard ; Mertz, Kenneth Hudlebusch ; Garne, Eva Stahl ; Schacht, Simon Rønnow ; Bin Ahmad, Hajar Fauzan ; Kot, Witold Piotr ; Hansen, Lars H ; Perez-Cueto Eulert, Federico Jose Armando ; Lind, Mads Vendelbo ; Juul Lassen, Aske ; Tetens, Inge ; Jensen, Tenna ; Reitelseder, Søren ; Jespersen, Astrid Pernille ; Holm, Lars ; Engelsen, Søren Balling ; Nielsen, Dennis Sandris. / Physical fitness in community-dwelling older adults is linked to dietary intake, gut microbiota, and metabolomic signatures. In: Aging Cell. 2020.

Bibtex

@article{1293076d9f964085992582af49f9cf0e,
title = "Physical fitness in community-dwelling older adults is linked to dietary intake, gut microbiota, and metabolomic signatures",
abstract = "When humans age, changes in body composition arise along with lifestyle-associated disorders influencing fitness and physical decline. Here we provide a comprehensive view of dietary intake, physical activity, gut microbiota (GM), and host metabolome in relation to physical fitness of 207 community-dwelling subjects aged +65 years. Stratification on anthropometric/body composition/physical performance measurements (ABPm) variables identified two phenotypes (high/low-fitness) clearly linked to dietary intake, physical activity, GM, and host metabolome patterns. Strikingly, despite a higher energy intake high-fitness subjects were characterized by leaner bodies and lower fasting proinsulin-C-peptide/blood glucose levels in a mechanism likely driven by higher dietary fiber intake, physical activity and increased abundance of Bifidobacteriales and Clostridiales species in GM and associated metabolites (i.e., enterolactone). These factors explained 50.1% of the individual variation in physical fitness. We propose that targeting dietary strategies for modulation of GM and host metabolome interactions may allow establishing therapeutic approaches to delay and possibly revert comorbidities of aging.Keywords: aging; energy and dietary fiber intake; gut microbiota; host metabolome; physical fitness; proinsulin-C-peptide.",
author = "Castro-Mej{\'i}a, {Josu{\'e} Leonardo} and Bekzod Khakimov and Lukasz Krych and Jacob B{\"u}low and Rasmus Bechshoeft and H{\o}jfeldt, {Grith Westergaard} and Mertz, {Kenneth Hudlebusch} and Garne, {Eva Stahl} and Schacht, {Simon R{\o}nnow} and {Bin Ahmad}, {Hajar Fauzan} and Kot, {Witold Piotr} and Hansen, {Lars H} and {Perez-Cueto Eulert}, {Federico Jose Armando} and Lind, {Mads Vendelbo} and {Juul Lassen}, Aske and Inge Tetens and Tenna Jensen and S{\o}ren Reitelseder and Jespersen, {Astrid Pernille} and Lars Holm and Engelsen, {S{\o}ren Balling} and Nielsen, {Dennis Sandris}",
year = "2020",
month = mar,
language = "English",
journal = "Aging Cell",
issn = "1474-9718",
publisher = "Wiley-Blackwell Publishing Ltd",

}

RIS

TY - JOUR

T1 - Physical fitness in community-dwelling older adults is linked to dietary intake, gut microbiota, and metabolomic signatures

AU - Castro-Mejía, Josué Leonardo

AU - Khakimov, Bekzod

AU - Krych, Lukasz

AU - Bülow, Jacob

AU - Bechshoeft, Rasmus

AU - Højfeldt, Grith Westergaard

AU - Mertz, Kenneth Hudlebusch

AU - Garne, Eva Stahl

AU - Schacht, Simon Rønnow

AU - Bin Ahmad, Hajar Fauzan

AU - Kot, Witold Piotr

AU - Hansen, Lars H

AU - Perez-Cueto Eulert, Federico Jose Armando

AU - Lind, Mads Vendelbo

AU - Juul Lassen, Aske

AU - Tetens, Inge

AU - Jensen, Tenna

AU - Reitelseder, Søren

AU - Jespersen, Astrid Pernille

AU - Holm, Lars

AU - Engelsen, Søren Balling

AU - Nielsen, Dennis Sandris

PY - 2020/3

Y1 - 2020/3

N2 - When humans age, changes in body composition arise along with lifestyle-associated disorders influencing fitness and physical decline. Here we provide a comprehensive view of dietary intake, physical activity, gut microbiota (GM), and host metabolome in relation to physical fitness of 207 community-dwelling subjects aged +65 years. Stratification on anthropometric/body composition/physical performance measurements (ABPm) variables identified two phenotypes (high/low-fitness) clearly linked to dietary intake, physical activity, GM, and host metabolome patterns. Strikingly, despite a higher energy intake high-fitness subjects were characterized by leaner bodies and lower fasting proinsulin-C-peptide/blood glucose levels in a mechanism likely driven by higher dietary fiber intake, physical activity and increased abundance of Bifidobacteriales and Clostridiales species in GM and associated metabolites (i.e., enterolactone). These factors explained 50.1% of the individual variation in physical fitness. We propose that targeting dietary strategies for modulation of GM and host metabolome interactions may allow establishing therapeutic approaches to delay and possibly revert comorbidities of aging.Keywords: aging; energy and dietary fiber intake; gut microbiota; host metabolome; physical fitness; proinsulin-C-peptide.

AB - When humans age, changes in body composition arise along with lifestyle-associated disorders influencing fitness and physical decline. Here we provide a comprehensive view of dietary intake, physical activity, gut microbiota (GM), and host metabolome in relation to physical fitness of 207 community-dwelling subjects aged +65 years. Stratification on anthropometric/body composition/physical performance measurements (ABPm) variables identified two phenotypes (high/low-fitness) clearly linked to dietary intake, physical activity, GM, and host metabolome patterns. Strikingly, despite a higher energy intake high-fitness subjects were characterized by leaner bodies and lower fasting proinsulin-C-peptide/blood glucose levels in a mechanism likely driven by higher dietary fiber intake, physical activity and increased abundance of Bifidobacteriales and Clostridiales species in GM and associated metabolites (i.e., enterolactone). These factors explained 50.1% of the individual variation in physical fitness. We propose that targeting dietary strategies for modulation of GM and host metabolome interactions may allow establishing therapeutic approaches to delay and possibly revert comorbidities of aging.Keywords: aging; energy and dietary fiber intake; gut microbiota; host metabolome; physical fitness; proinsulin-C-peptide.

M3 - Journal article

JO - Aging Cell

JF - Aging Cell

SN - 1474-9718

ER -

ID: 61764075