TY - JOUR
T1 - Physical exercise may increase plasma concentration of high-density lipoprotein-cholesterol in patients with alzheimer's disease
AU - Jensen, Camilla Steen
AU - Musaeus, Christian Sandøe
AU - Frikke-Schmidt, Ruth
AU - Andersen, Birgitte Bo
AU - Beyer, Nina
AU - Gottrup, Hanne
AU - Høgh, Peter
AU - Vestergaard, Karsten
AU - Wermuth, Lene
AU - Frederiksen, Kristian Steen
AU - Waldemar, Gunhild
AU - Hasselbalch, Steen
AU - Simonsen, Anja Hviid
N1 - Copyright © 2020 Jensen, Musaeus, Frikke-Schmidt, Andersen, Beyer, Gottrup, Høgh, Vestergaard, Wermuth, Frederiksen, Waldemar, Hasselbalch and Simonsen.
PY - 2020
Y1 - 2020
N2 - Lifestyle factors have been shown to increase the risk of developing Alzheimer's disease (AD) later in life. Specifically, an unfavorable cholesterol profile, and insulin resistance are associated with increased risk of developing AD. One way to non-pharmacologically affect the levels of plasma lipids is by exercise, which has been shown to be beneficial in cognitively healthy individuals. In this randomized controlled trial y, we therefore aimed to clarify the effect of physical exercise on the lipid profile, insulin and glucose in patients with AD. In addition, we investigated the effect of apolipoproteinE genotype on total cholesterol, high-density lipoprotein-cholesterol (HDL-C), low-density lipoprotein-cholesterol (LDL-C), and triglycerides (TG) in plasma from patients with AD. Plasma samples from 172 patients who underwent 16 weeks of moderate-to-high intensity exercise (n = 90) or treatment as usual (n = 82) were analyzed change from baseline for the levels of total cholesterol, LDL-C, HDL-C, TG, glucose, and insulin. In addition, we analyzed those from the exercise group who adhered to the protocol with an attendance of 2/3 or more of the exercise session and who followed the protocol of an intensity of 70% of the maximum heart rate. We found a significant increase in plasma HDL-C levels between the "high exercise sub-group" compared to control group. After intervention HDL-C was increased by 4.3% in the high-exercise group, and decreased by 0.7% in the control group, after adjustment for statin use. In conclusion, short term physical activity may be beneficial on the cholesterol profile in patients with AD.
AB - Lifestyle factors have been shown to increase the risk of developing Alzheimer's disease (AD) later in life. Specifically, an unfavorable cholesterol profile, and insulin resistance are associated with increased risk of developing AD. One way to non-pharmacologically affect the levels of plasma lipids is by exercise, which has been shown to be beneficial in cognitively healthy individuals. In this randomized controlled trial y, we therefore aimed to clarify the effect of physical exercise on the lipid profile, insulin and glucose in patients with AD. In addition, we investigated the effect of apolipoproteinE genotype on total cholesterol, high-density lipoprotein-cholesterol (HDL-C), low-density lipoprotein-cholesterol (LDL-C), and triglycerides (TG) in plasma from patients with AD. Plasma samples from 172 patients who underwent 16 weeks of moderate-to-high intensity exercise (n = 90) or treatment as usual (n = 82) were analyzed change from baseline for the levels of total cholesterol, LDL-C, HDL-C, TG, glucose, and insulin. In addition, we analyzed those from the exercise group who adhered to the protocol with an attendance of 2/3 or more of the exercise session and who followed the protocol of an intensity of 70% of the maximum heart rate. We found a significant increase in plasma HDL-C levels between the "high exercise sub-group" compared to control group. After intervention HDL-C was increased by 4.3% in the high-exercise group, and decreased by 0.7% in the control group, after adjustment for statin use. In conclusion, short term physical activity may be beneficial on the cholesterol profile in patients with AD.
KW - Alzheimer’s disease
KW - cholesterol
KW - exercise
KW - fitness
KW - HDL-C
KW - lipid profile
UR - http://www.scopus.com/inward/record.url?scp=85086342081&partnerID=8YFLogxK
U2 - 10.3389/fnins.2020.00532
DO - 10.3389/fnins.2020.00532
M3 - Journal article
C2 - 32536853
SN - 1662-4548
VL - 14
JO - Frontiers in Neuroscience
JF - Frontiers in Neuroscience
M1 - 532
ER -