Physical activity attenuates the influence of FTO variants on obesity risk: a meta-analysis of 218,166 adults and 19,268 children

Tuomas Kilpeläinen; Lu Qi; Soren Brage; Stephen J Sharp; Emily Sonestedt; Ellen Demerath; Tariq Ahmad; Samia Mora; Marika Kaakinen; Camilla Helene Sandholt; Christina Holzapfel; Christine S Autenrieth; Elina Hyppönen; Stéphane Cauchi; Meian He; Zoltan Kutalik; Meena Kumari; Alena Stančáková; Karina Meidtner; Beverley Balkau; Jonathan T Tan; Massimo Mangino; Nicholas J Timpson; Yiqing Song; M Carola Zillikens; Kathleen A Jablonski; Melissa E Garcia; Stefan Johansson; Jennifer L Bragg-Gresham; Ying Wu; Jana V van Vliet-Ostaptchouk; N Charlotte Onland-Moret; Esther Zimmermann; Natalia V Rivera; Toshiko Tanaka; Heather M Stringham; Günther Silbernagel; Stavroula Kanoni; Mary F Feitosa; Soren Snitker; Jonatan R Ruiz; Jeffery Metter; Maria Teresa Martinez Larrad; Mustafa Atalay; Maarit Hakanen; Najaf Amin; Christine Cavalcanti-Proença; Anders Grøntved; Göran Hallmans; John-Olov Jansson; Johanna Kuusisto; Mika Kähönen; Pamela L Lutsey; John Nolan; Luigi Palla; Oluf Borbye Pedersen; Louis Pérusse; Frida Renström; Robert A Scott; Dmitry Shungin; Ulla Sovio; Tuija H Tammelin; Tapani Rönnemaa; Timo A Lakka; Matti Uusitupa; Manuel Serrano Rios; Luigi Ferrucci; Claude Bouchard; Aline Meirhaeghe; Mao Fu; Mark Walker; Ingrid B Borecki; George V Dedoussis; Andreas Fritsche; Claes Ohlsson; Michael Boehnke; Stefania Bandinelli; Cornelia M van Duijn; Shah Ebrahim; Debbie A Lawlor; Vilmundur Gudnason; Tamara B Harris; Thorkild I A Sørensen; Karen L Mohlke; Albert Hofman; André G Uitterlinden; Jaakko Tuomilehto; Terho Lehtimäki; Olli Raitakari; Bo Isomaa; Pål R Njølstad; Jose C Florez; Simin Liu; Andy Ness; Timothy D Spector; E Shyong Tai; Philippe Froguel; Heiner Boeing; Markku Laakso; Michael Marmot; Sven Bergmann; Chris Power; Kay-Tee Khaw; Daniel Chasman; Paul Ridker; Torben Hansen; Keri L Monda; Thomas Illig; Marjo-Riitta Järvelin; Nicholas J Wareham; Frank B Hu; Leif C Groop; Marju Orho-Melander; Ulf Ekelund; Paul W Franks; Ruth J F Loos

doi:10.1371/journal.pmed.1001116

Physical activity attenuates the influence of FTO variants on obesity risk: a meta-analysis of 218,166 adults and 19,268 children

Tuomas Kilpeläinen, Lu Qi, Soren Brage, Stephen J Sharp, Emily Sonestedt, Ellen Demerath, Tariq Ahmad, Samia Mora, Marika Kaakinen, Camilla Helene Sandholt, Christina Holzapfel, Christine S Autenrieth, Elina Hyppönen, Stéphane Cauchi, Meian He, Zoltan Kutalik, Meena Kumari, Alena Stančáková, Karina Meidtner, Beverley BalkauJonathan T Tan, Massimo Mangino, Nicholas J Timpson, Yiqing Song, M Carola Zillikens, Kathleen A Jablonski, Melissa E Garcia, Stefan Johansson, Jennifer L Bragg-Gresham, Ying Wu, Jana V van Vliet-Ostaptchouk, N Charlotte Onland-Moret, Esther Zimmermann, Natalia V Rivera, Toshiko Tanaka, Heather M Stringham, Günther Silbernagel, Stavroula Kanoni, Mary F Feitosa, Soren Snitker, Jonatan R Ruiz, Jeffery Metter, Maria Teresa Martinez Larrad, Mustafa Atalay, Maarit Hakanen, Najaf Amin, Christine Cavalcanti-Proença, Anders Grøntved, Göran Hallmans, John-Olov Jansson, Johanna Kuusisto, Mika Kähönen, Pamela L Lutsey, John Nolan, Luigi Palla, Oluf Borbye Pedersen, Louis Pérusse, Frida Renström, Robert A Scott, Dmitry Shungin, Ulla Sovio, Tuija H Tammelin, Tapani Rönnemaa, Timo A Lakka, Matti Uusitupa, Manuel Serrano Rios, Luigi Ferrucci, Claude Bouchard, Aline Meirhaeghe, Mao Fu, Mark Walker, Ingrid B Borecki, George V Dedoussis, Andreas Fritsche, Claes Ohlsson, Michael Boehnke, Stefania Bandinelli, Cornelia M van Duijn, Shah Ebrahim, Debbie A Lawlor, Vilmundur Gudnason, Tamara B Harris, Thorkild I A Sørensen, Karen L Mohlke, Albert Hofman, André G Uitterlinden, Jaakko Tuomilehto, Terho Lehtimäki, Olli Raitakari, Bo Isomaa, Pål R Njølstad, Jose C Florez, Simin Liu, Andy Ness, Timothy D Spector, E Shyong Tai, Philippe Froguel, Heiner Boeing, Markku Laakso, Michael Marmot, Sven Bergmann, Chris Power, Kay-Tee Khaw, Daniel Chasman, Paul Ridker, Torben Hansen, Keri L Monda, Thomas Illig, Marjo-Riitta Järvelin, Nicholas J Wareham, Frank B Hu, Leif C Groop, Marju Orho-Melander, Ulf Ekelund, Paul W Franks, Ruth J F Loos

440 Citations (Scopus)

Abstract

The FTO gene harbors the strongest known susceptibility locus for obesity. While many individual studies have suggested that physical activity (PA) may attenuate the effect of FTO on obesity risk, other studies have not been able to confirm this interaction. To confirm or refute unambiguously whether PA attenuates the association of FTO with obesity risk, we meta-analyzed data from 45 studies of adults (n = 218,166) and nine studies of children and adolescents (n = 19,268).

Original language	English
Journal	PLOS Medicine
Volume	8
Issue number	11
Pages (from-to)	e1001116
ISSN	1549-1676
DOIs	https://doi.org/10.1371/journal.pmed.1001116
Publication status	Published - 2011

Keywords

Adipose Tissue
Adolescent
Adult
Aged
Child
Female
Genetic Predisposition to Disease
Genotype
Humans
Male
Motor Activity
Obesity
Polymorphism, Single Nucleotide
Proteins
Risk Factors

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Kilpeläinen, T., Qi, L., Brage, S., Sharp, S. J., Sonestedt, E., Demerath, E., Ahmad, T., Mora, S., Kaakinen, M., Sandholt, C. H., Holzapfel, C., Autenrieth, C. S., Hyppönen, E., Cauchi, S., He, M., Kutalik, Z., Kumari, M., Stančáková, A., Meidtner, K., ... Loos, R. J. F. (2011). Physical activity attenuates the influence of FTO variants on obesity risk: a meta-analysis of 218,166 adults and 19,268 children. PLOS Medicine, 8(11), e1001116. https://doi.org/10.1371/journal.pmed.1001116

Kilpeläinen, T, Qi, L, Brage, S, Sharp, SJ, Sonestedt, E, Demerath, E, Ahmad, T, Mora, S, Kaakinen, M, Sandholt, CH, Holzapfel, C, Autenrieth, CS, Hyppönen, E, Cauchi, S, He, M, Kutalik, Z, Kumari, M, Stančáková, A, Meidtner, K, Balkau, B, Tan, JT, Mangino, M, Timpson, NJ, Song, Y, Zillikens, MC, Jablonski, KA, Garcia, ME, Johansson, S, Bragg-Gresham, JL, Wu, Y, van Vliet-Ostaptchouk, JV, Onland-Moret, NC, Zimmermann, E, Rivera, NV, Tanaka, T, Stringham, HM, Silbernagel, G, Kanoni, S, Feitosa, MF, Snitker, S, Ruiz, JR, Metter, J, Larrad, MTM, Atalay, M, Hakanen, M, Amin, N, Cavalcanti-Proença, C, Grøntved, A, Hallmans, G, Jansson, J-O, Kuusisto, J, Kähönen, M, Lutsey, PL, Nolan, J, Palla, L, Pedersen, OB, Pérusse, L, Renström, F, Scott, RA, Shungin, D, Sovio, U, Tammelin, TH, Rönnemaa, T, Lakka, TA, Uusitupa, M, Rios, MS, Ferrucci, L, Bouchard, C, Meirhaeghe, A, Fu, M, Walker, M, Borecki, IB, Dedoussis, GV, Fritsche, A, Ohlsson, C, Boehnke, M, Bandinelli, S, van Duijn, CM, Ebrahim, S, Lawlor, DA, Gudnason, V, Harris, TB, Sørensen, TIA, Mohlke, KL, Hofman, A, Uitterlinden, AG, Tuomilehto, J, Lehtimäki, T, Raitakari, O, Isomaa, B, Njølstad, PR, Florez, JC, Liu, S, Ness, A, Spector, TD, Tai, ES, Froguel, P, Boeing, H, Laakso, M, Marmot, M, Bergmann, S, Power, C, Khaw, K-T, Chasman, D, Ridker, P, Hansen, T, Monda, KL, Illig, T, Järvelin, M-R, Wareham, NJ, Hu, FB, Groop, LC, Orho-Melander, M, Ekelund, U, Franks, PW & Loos, RJF 2011, 'Physical activity attenuates the influence of FTO variants on obesity risk: a meta-analysis of 218,166 adults and 19,268 children', PLOS Medicine, vol. 8, no. 11, pp. e1001116. https://doi.org/10.1371/journal.pmed.1001116

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abstract = "The FTO gene harbors the strongest known susceptibility locus for obesity. While many individual studies have suggested that physical activity (PA) may attenuate the effect of FTO on obesity risk, other studies have not been able to confirm this interaction. To confirm or refute unambiguously whether PA attenuates the association of FTO with obesity risk, we meta-analyzed data from 45 studies of adults (n = 218,166) and nine studies of children and adolescents (n = 19,268).",

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year = "2011",

doi = "10.1371/journal.pmed.1001116",

language = "English",

volume = "8",

pages = "e1001116",

journal = "PLOS Medicine",

issn = "1549-1676",

publisher = "Public Library of Science",

number = "11",

}

TY - JOUR

T1 - Physical activity attenuates the influence of FTO variants on obesity risk

T2 - a meta-analysis of 218,166 adults and 19,268 children

AU - Kilpeläinen, Tuomas

AU - Qi, Lu

AU - Brage, Soren

AU - Sharp, Stephen J

AU - Sonestedt, Emily

AU - Demerath, Ellen

AU - Ahmad, Tariq

AU - Mora, Samia

AU - Kaakinen, Marika

AU - Sandholt, Camilla Helene

AU - Holzapfel, Christina

AU - Autenrieth, Christine S

AU - Hyppönen, Elina

AU - Cauchi, Stéphane

AU - He, Meian

AU - Kutalik, Zoltan

AU - Kumari, Meena

AU - Stančáková, Alena

AU - Meidtner, Karina

AU - Balkau, Beverley

AU - Tan, Jonathan T

AU - Mangino, Massimo

AU - Timpson, Nicholas J

AU - Song, Yiqing

AU - Zillikens, M Carola

AU - Jablonski, Kathleen A

AU - Garcia, Melissa E

AU - Johansson, Stefan

AU - Bragg-Gresham, Jennifer L

AU - Wu, Ying

AU - van Vliet-Ostaptchouk, Jana V

AU - Onland-Moret, N Charlotte

AU - Zimmermann, Esther

AU - Rivera, Natalia V

AU - Tanaka, Toshiko

AU - Stringham, Heather M

AU - Silbernagel, Günther

AU - Kanoni, Stavroula

AU - Feitosa, Mary F

AU - Snitker, Soren

AU - Ruiz, Jonatan R

AU - Metter, Jeffery

AU - Larrad, Maria Teresa Martinez

AU - Atalay, Mustafa

AU - Hakanen, Maarit

AU - Amin, Najaf

AU - Cavalcanti-Proença, Christine

AU - Grøntved, Anders

AU - Hallmans, Göran

AU - Jansson, John-Olov

AU - Kuusisto, Johanna

AU - Kähönen, Mika

AU - Lutsey, Pamela L

AU - Nolan, John

AU - Palla, Luigi

AU - Pedersen, Oluf Borbye

AU - Pérusse, Louis

AU - Renström, Frida

AU - Scott, Robert A

AU - Shungin, Dmitry

AU - Sovio, Ulla

AU - Tammelin, Tuija H

AU - Rönnemaa, Tapani

AU - Lakka, Timo A

AU - Uusitupa, Matti

AU - Rios, Manuel Serrano

AU - Ferrucci, Luigi

AU - Bouchard, Claude

AU - Meirhaeghe, Aline

AU - Fu, Mao

AU - Walker, Mark

AU - Borecki, Ingrid B

AU - Dedoussis, George V

AU - Fritsche, Andreas

AU - Ohlsson, Claes

AU - Boehnke, Michael

AU - Bandinelli, Stefania

AU - van Duijn, Cornelia M

AU - Ebrahim, Shah

AU - Lawlor, Debbie A

AU - Gudnason, Vilmundur

AU - Harris, Tamara B

AU - Sørensen, Thorkild I A

AU - Mohlke, Karen L

AU - Hofman, Albert

AU - Uitterlinden, André G

AU - Tuomilehto, Jaakko

AU - Lehtimäki, Terho

AU - Raitakari, Olli

AU - Isomaa, Bo

AU - Njølstad, Pål R

AU - Florez, Jose C

AU - Liu, Simin

AU - Ness, Andy

AU - Spector, Timothy D

AU - Tai, E Shyong

AU - Froguel, Philippe

AU - Boeing, Heiner

AU - Laakso, Markku

AU - Marmot, Michael

AU - Bergmann, Sven

AU - Power, Chris

AU - Khaw, Kay-Tee

AU - Chasman, Daniel

AU - Ridker, Paul

AU - Hansen, Torben

AU - Monda, Keri L

AU - Illig, Thomas

AU - Järvelin, Marjo-Riitta

AU - Wareham, Nicholas J

AU - Hu, Frank B

AU - Groop, Leif C

AU - Orho-Melander, Marju

AU - Ekelund, Ulf

AU - Franks, Paul W

AU - Loos, Ruth J F

PY - 2011

Y1 - 2011

N2 - The FTO gene harbors the strongest known susceptibility locus for obesity. While many individual studies have suggested that physical activity (PA) may attenuate the effect of FTO on obesity risk, other studies have not been able to confirm this interaction. To confirm or refute unambiguously whether PA attenuates the association of FTO with obesity risk, we meta-analyzed data from 45 studies of adults (n = 218,166) and nine studies of children and adolescents (n = 19,268).

AB - The FTO gene harbors the strongest known susceptibility locus for obesity. While many individual studies have suggested that physical activity (PA) may attenuate the effect of FTO on obesity risk, other studies have not been able to confirm this interaction. To confirm or refute unambiguously whether PA attenuates the association of FTO with obesity risk, we meta-analyzed data from 45 studies of adults (n = 218,166) and nine studies of children and adolescents (n = 19,268).

KW - Adipose Tissue

KW - Adolescent

KW - Adult

KW - Aged

KW - Child

KW - Female

KW - Genetic Predisposition to Disease

KW - Genotype

KW - Humans

KW - Male

KW - Motor Activity

KW - Obesity

KW - Polymorphism, Single Nucleotide

KW - Proteins

KW - Risk Factors

U2 - 10.1371/journal.pmed.1001116

DO - 10.1371/journal.pmed.1001116

M3 - Journal article

C2 - 22069379

SN - 1549-1676

VL - 8

SP - e1001116

JO - PLOS Medicine

JF - PLOS Medicine

IS - 11

ER -

Physical activity attenuates the influence of FTO variants on obesity risk: a meta-analysis of 218,166 adults and 19,268 children

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Keywords

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