Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital

Physical Activity and Subsequent Change in Body Weight, Composition and Shape: Effect Modification by Familial Overweight

Research output: Contribution to journalJournal articlepeer-review

  1. Characterization and Survival of Human Infant Testicular Cells After Direct Xenotransplantation

    Research output: Contribution to journalJournal articlepeer-review

  2. Absence of P2Y2 receptor does not prevent bone destruction in a murine model of muscle paralysis-Induced bone loss

    Research output: Contribution to journalJournal articlepeer-review

  3. Case Report: Giant Paraganglioma of the Skull Base With Two Somatic Mutations in SDHB and PTEN Genes

    Research output: Contribution to journalJournal articlepeer-review

View graph of relations

Background: Physical activity (PA) has been shown to attenuate the genetic risk of obesity as measured using polygenic risk scores. However, familial obesity history might be an easier predictor. We examined associations between PA and subsequent changes in BMI, body fat percentage (BF%) and waist circumference (WC) among participants with and without adiposity and a familial overweight.

Methods: In total, 1971 participants from the Danish MONICA cohort were included. Mean differences for 6-year changes in BMI, BF% and WC across PA levels were estimated. Association between walking and biking and subsequent change in adiposity were analysed. Effect modification by familial obesity was assessed by adding product terms to the models.

Results: We observed weak associations between leisure PA level and changes in WC [participants with low PA: 3.4 cm (95%CI: 2.8;4.0), participants with high PA: 2.4 cm (95%CI: 1.8;3.0)], with no evidence of effect modification by familial obesity. We found effect modification in analyses on walking and biking in relation to changes in BMI (P-interaction<0.01) and BF% (P-interaction=0.04), suggesting lower gain with more hours of activity among participants with adiposity and familial overweight.

Conclusions: The results were modest but suggested that PA, especially walking and biking, may prevent future adiposity.

Original languageEnglish
Article number787827
JournalFrontiers in Endocrinology
Pages (from-to)787827
Publication statusPublished - 2022

Bibliographical note

Copyright © 2022 Specht, Heitmann and Larsen.

ID: 75621248