TY - JOUR
T1 - Physical Activity and Sleep in 11-Year Old Children With a Familial High Risk of Schizophrenia or Bipolar Disorder. The Danish High Risk and Resilience Study-VIA 11
AU - Søndergaard, Anne
AU - Wilms, Martin
AU - Gregersen, Maja
AU - Brandt, Julie Marie
AU - Krantz, Mette Falkenberg
AU - Rohd, Sinnika Birkehøj
AU - Johnsen, Line Korsgaard
AU - Hemager, Nicoline
AU - Hjorthøj, Carsten
AU - Ohland, Jessica
AU - Andreassen, Anna Krogh
AU - Knudsen, Christina Bruun
AU - Veddum, Lotte
AU - Greve, Aja
AU - Bliksted, Vibeke
AU - Mors, Ole
AU - Krustrup, Peter
AU - Thorsteinsson, Troels
AU - Schmidt-Andersen, Peter
AU - Kjærgaard, Morten
AU - Lykkegaard, Kasper
AU - Thorup, Anne Amalie Elgaard
AU - Nordentoft, Merete
N1 - © The Author(s) 2021. Published by Oxford University Press on behalf of the University of Maryland’s school of medicine, Maryland Psychiatric Research Center.
PY - 2022/1
Y1 - 2022/1
N2 - OBJECTIVE: People with schizophrenia and bipolar disorder are at increased risk of having comorbid somatic illness. This is partly due to lack of physical activity, which may originate from childhood. Sleep disturbances are associated with schizophrenia and bipolar disorder. We aimed to assess physical activity and sleep in children at familial high risk of schizophrenia or bipolar disorder and population-based controls.METHODS: This study is part of The Danish High Risk and Resilience Study-VIA 11. Children aged 11 born to parents with schizophrenia (FHR-SZ) (N = 133), bipolar disorder (FHR-BP) (N = 84), or controls (C) (N = 150) were assessed by accelerometry for an average of 6.9 days.RESULTS: High-intensity physical activity was significantly lower in children at FHR-SZ and FHR-BP compared to controls, (mean hours per day for FHR-SZ: 0.29, SD 0.19, for FHR-BP: 0.27, SD 0.24, and for controls 0.38, SD 0.22, P = <.001). Sleep did not differ between the groups.CONCLUSION: Children at FHR-SZ or FHR-BP had less physical activity compared to controls. Our study highlights a research area that reveals a hitherto unexplored disadvantage of being born to parents with schizophrenia or bipolar disorder. Further research is needed to enhance better understanding of causal pathways and consequences of reduced physical activity in children with FHR-SZ and FHR-BP.
AB - OBJECTIVE: People with schizophrenia and bipolar disorder are at increased risk of having comorbid somatic illness. This is partly due to lack of physical activity, which may originate from childhood. Sleep disturbances are associated with schizophrenia and bipolar disorder. We aimed to assess physical activity and sleep in children at familial high risk of schizophrenia or bipolar disorder and population-based controls.METHODS: This study is part of The Danish High Risk and Resilience Study-VIA 11. Children aged 11 born to parents with schizophrenia (FHR-SZ) (N = 133), bipolar disorder (FHR-BP) (N = 84), or controls (C) (N = 150) were assessed by accelerometry for an average of 6.9 days.RESULTS: High-intensity physical activity was significantly lower in children at FHR-SZ and FHR-BP compared to controls, (mean hours per day for FHR-SZ: 0.29, SD 0.19, for FHR-BP: 0.27, SD 0.24, and for controls 0.38, SD 0.22, P = <.001). Sleep did not differ between the groups.CONCLUSION: Children at FHR-SZ or FHR-BP had less physical activity compared to controls. Our study highlights a research area that reveals a hitherto unexplored disadvantage of being born to parents with schizophrenia or bipolar disorder. Further research is needed to enhance better understanding of causal pathways and consequences of reduced physical activity in children with FHR-SZ and FHR-BP.
KW - Schizoprenia
KW - bipolar disorder
KW - children
KW - high risk
KW - physical activity
UR - http://www.scopus.com/inward/record.url?scp=85130809643&partnerID=8YFLogxK
U2 - 10.1093/schizbullopen/sgab055
DO - 10.1093/schizbullopen/sgab055
M3 - Journal article
C2 - 39144806
SN - 2632-7899
VL - 3
SP - gab055
JO - Schizophrenia Bulletin Open
JF - Schizophrenia Bulletin Open
IS - 1
M1 - sgab055
ER -