Photoreceptor atrophy in acute zonal occult outer retinopathy

Nathalie Zibrandtsen; Inger Christine Munch; Kristian Klemp; Thomas Martini Jørgensen; Birgit Sander; Michael Larsen

doi:10.1111/j.1600-0420.2007.01140.x

Photoreceptor atrophy in acute zonal occult outer retinopathy

Nathalie Zibrandtsen, Inger Christine Munch, Kristian Klemp, Thomas Martini Jørgensen, Birgit Sander, Michael Larsen

Department of Ophthalmology

34 Citations (Scopus)

Abstract

PURPOSE: To assess retinal morphology in acute zonal occult outer retinopathy (AZOOR) without ophthalmoscopically visible fundus changes.

METHODS: Retrospective case series. Two consecutive patients with bilateral AZOOR with photopsia corresponding to areas of visual field loss and a normal fundus appearance were examined using optical coherence tomography (OCT), automated perimetry and electroretinography (ERG).

RESULTS: Both patients demonstrated photoreceptor atrophy corresponding to partial or complete scotomata with reduced or extinct electroretinographic responses. Attenuation or complete loss of all the segments composing the photoreceptor layer was found by OCT. Full-field ERG revealed affection of the 30 Hz flicker responses and subnormal photopic responses in both patients and subnormal scotopic responses in case 1. Multifocal electroretinography (mERG) revealed localized outer retinal dysfunction. The field loss was more extensive than the area of photoreceptor loss.

CONCLUSION: Photoreceptor atrophy can be demonstrated in AZOOR without ophthalmoscopically visible fundus lesions.

Original language	English
Journal	Acta Ophthalmologica (Online)
Volume	86
Issue number	8
Pages (from-to)	913-6
Number of pages	4
ISSN	1755-3768
DOIs	https://doi.org/10.1111/j.1600-0420.2007.01140.x
Publication status	Published - Dec 2008

Keywords

Acute Disease
Adolescent
Atrophy
Automation
Electroretinography
Female
Humans
Male
Middle Aged
Photoreceptor Cells/pathology
Retinal Diseases/complications
Retrospective Studies
Scotoma/diagnosis
Tomography, Optical Coherence
Vision Disorders/etiology
Visual Field Tests/methods
Visual Fields

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10.1111/j.1600-0420.2007.01140.x

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title = "Photoreceptor atrophy in acute zonal occult outer retinopathy",

abstract = "PURPOSE: To assess retinal morphology in acute zonal occult outer retinopathy (AZOOR) without ophthalmoscopically visible fundus changes.METHODS: Retrospective case series. Two consecutive patients with bilateral AZOOR with photopsia corresponding to areas of visual field loss and a normal fundus appearance were examined using optical coherence tomography (OCT), automated perimetry and electroretinography (ERG).RESULTS: Both patients demonstrated photoreceptor atrophy corresponding to partial or complete scotomata with reduced or extinct electroretinographic responses. Attenuation or complete loss of all the segments composing the photoreceptor layer was found by OCT. Full-field ERG revealed affection of the 30 Hz flicker responses and subnormal photopic responses in both patients and subnormal scotopic responses in case 1. Multifocal electroretinography (mERG) revealed localized outer retinal dysfunction. The field loss was more extensive than the area of photoreceptor loss.CONCLUSION: Photoreceptor atrophy can be demonstrated in AZOOR without ophthalmoscopically visible fundus lesions.",

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author = "Nathalie Zibrandtsen and Munch, \{Inger Christine\} and Kristian Klemp and J{\o}rgensen, \{Thomas Martini\} and Birgit Sander and Michael Larsen",

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doi = "10.1111/j.1600-0420.2007.01140.x",

language = "English",

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T1 - Photoreceptor atrophy in acute zonal occult outer retinopathy

AU - Zibrandtsen, Nathalie

AU - Munch, Inger Christine

AU - Klemp, Kristian

AU - Jørgensen, Thomas Martini

AU - Sander, Birgit

AU - Larsen, Michael

PY - 2008/12

Y1 - 2008/12

N2 - PURPOSE: To assess retinal morphology in acute zonal occult outer retinopathy (AZOOR) without ophthalmoscopically visible fundus changes.METHODS: Retrospective case series. Two consecutive patients with bilateral AZOOR with photopsia corresponding to areas of visual field loss and a normal fundus appearance were examined using optical coherence tomography (OCT), automated perimetry and electroretinography (ERG).RESULTS: Both patients demonstrated photoreceptor atrophy corresponding to partial or complete scotomata with reduced or extinct electroretinographic responses. Attenuation or complete loss of all the segments composing the photoreceptor layer was found by OCT. Full-field ERG revealed affection of the 30 Hz flicker responses and subnormal photopic responses in both patients and subnormal scotopic responses in case 1. Multifocal electroretinography (mERG) revealed localized outer retinal dysfunction. The field loss was more extensive than the area of photoreceptor loss.CONCLUSION: Photoreceptor atrophy can be demonstrated in AZOOR without ophthalmoscopically visible fundus lesions.

AB - PURPOSE: To assess retinal morphology in acute zonal occult outer retinopathy (AZOOR) without ophthalmoscopically visible fundus changes.METHODS: Retrospective case series. Two consecutive patients with bilateral AZOOR with photopsia corresponding to areas of visual field loss and a normal fundus appearance were examined using optical coherence tomography (OCT), automated perimetry and electroretinography (ERG).RESULTS: Both patients demonstrated photoreceptor atrophy corresponding to partial or complete scotomata with reduced or extinct electroretinographic responses. Attenuation or complete loss of all the segments composing the photoreceptor layer was found by OCT. Full-field ERG revealed affection of the 30 Hz flicker responses and subnormal photopic responses in both patients and subnormal scotopic responses in case 1. Multifocal electroretinography (mERG) revealed localized outer retinal dysfunction. The field loss was more extensive than the area of photoreceptor loss.CONCLUSION: Photoreceptor atrophy can be demonstrated in AZOOR without ophthalmoscopically visible fundus lesions.

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KW - Electroretinography

KW - Female

KW - Humans

KW - Male

KW - Middle Aged

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KW - Retinal Diseases/complications

KW - Retrospective Studies

KW - Scotoma/diagnosis

KW - Tomography, Optical Coherence

KW - Vision Disorders/etiology

KW - Visual Field Tests/methods

KW - Visual Fields

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JO - Acta Ophthalmologica (Online)

JF - Acta Ophthalmologica (Online)

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ER -

Photoreceptor atrophy in acute zonal occult outer retinopathy

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