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The Capital Region of Denmark - a part of Copenhagen University Hospital
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Photodynamic therapy of necrobiosis lipoidica using methyl aminolevulinate: A retrospective follow-up study

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  1. Protoporphyrin IX formation after application of methyl aminolevulinate on the face and scalp with and without prior curettage

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  2. Intense phototoxic reactions to photodynamic therapy in immunosuppressed renal transplant patients

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  3. Diagnostic accuracy of optical coherence tomography in actinic keratosis and basal cell carcinoma

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  1. The background and philosophy behind daylight photodynamic therapy

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  2. Organ transplant recipients express enhanced skin autofluorescence and pigmentation at skin cancer sites

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  3. Protoporphyrin IX formation after application of methyl aminolevulinate on the face and scalp with and without prior curettage

    Research output: Contribution to journalJournal articleResearchpeer-review

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INTRODUCTION: Necrobiosis lipoidica (NL) is a rare, treatment-resistant, granulomatous skin disease of unknown origin, frequently seen in patients with diabetes.

METHODS: In this retrospective study we evaluated the long-term efficacy of methyl aminolaevulinate-based photodynamic therapy (MAL-PDT), including 80 treatments (70 conventional and 10 daylight PDT), on 65 unselected NL patients treated routinely in our clinic. Superficial curettage, avoiding skin oozing or bleeding, was performed prior to MAL application.

RESULTS: Conventional MAL-PDT had a 100% cure rate (CR) in 64% (45/70) of the treatment series. With daylight PDT we observed a 100% CR in 80% of the treatment series (8/10), an insignificant difference compared to conventional PDT (p = 0.48). The overall cure rate was 66% (53/80). We observed no correlation between CR and gender, age at first PDT treatment, duration of NL prior to PDT treatment, number of NL elements, or diabetes. New lesions faded, whereas old lesions were clearly visible after inactivation of NL.

DISCUSSION: MAL-PDT proved to have full efficacy in 66% of the treatments, with conventional PDT and daylight PDT producing an almost identical result. We observed no correlation between CR and time of follow-up. However, we recommend at least six months to pass before final evaluation of treatment effect.

Original languageEnglish
JournalPhotodiagnosis and Photodynamic Therapy
Volume22
Pages (from-to)223-226
Number of pages4
ISSN1572-1000
DOIs
Publication statusPublished - Jun 2018

ID: 55208033