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The Capital Region of Denmark - a part of Copenhagen University Hospital
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Phosphorylation of serine 248 of C/EBPα is dispensable for myelopoiesis but its disruption leads to a low penetrant myeloid disorder with long latency

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  2. Lipidomics of human adipose tissue reveals diversity between body areas

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  3. Dyslipidemia at diagnosis of childhood acute lymphoblastic leukemia

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  4. Risk for development of inflammatory bowel disease under inhibition of interleukin 17: A systematic review and meta-analysis

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  1. The ASXL1-G643W variant accelerates the development of CEBPA mutant acute myeloid leukemia

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  2. The prognostic effect of smoking status on intensively treated acute myeloid leukaemia - A Danish nationwide cohort study

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  3. Myelodysplastic syndrome patient-derived xenografts: from no options to many

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  4. ERG Controls B Cell Development by Promoting Igh V-to-DJ Recombination

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Transcription factors play a key role in lineage commitment and differentiation of stem cells into distinct mature cells. In hematopoiesis, they regulate lineage-specific gene expression in a stage-specific manner through various physical and functional interactions with regulatory proteins that are simultanously recruited and activated to ensure timely gene expression. The transcription factor CCAAT/enhancer binding protein α (C/EBPα) is such a factor and is essential for the development of granulocytic/monocytic cells. The activity of C/EBPα is regulated on several levels including gene expression, alternative translation, protein interactions and posttranslational modifications, such as phosphorylation. In particular, the phosphorylation of serine 248 of the transactivation domain has been shown to be of crucial importance for granulocytic differentiation of 32Dcl3 cells in vitro.
Original languageEnglish
JournalP L o S One
Volume7
Issue number6
Pages (from-to)e38841
ISSN1932-6203
DOIs
Publication statusPublished - 2012

ID: 36840304