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The Capital Region of Denmark - a part of Copenhagen University Hospital
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Phosphorylation of serine 248 of C/EBPα is dispensable for myelopoiesis but its disruption leads to a low penetrant myeloid disorder with long latency

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  1. Antigenic and immunogenic evaluation of permutations of soluble hepatitis C virus envelope protein E2 and E1 antigens

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  2. Dancing with atrial fibrillation - How arrhythmia affects everyday life of family members: A qualitative study

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  3. Endothelial glycocalyx and cardio-renal risk factors in type 1 diabetes

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  4. Insulin resistance genetic risk score and burden of coronary artery disease in patients referred for coronary angiography

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  1. Targeted inhibition of cooperative mutation- and therapy-induced AKT activation in AML effectively enhances response to chemotherapy

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  2. Quantitative single-cell proteomics as a tool to characterize cellular hierarchies

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  3. Basement membrane stiffness determines metastases formation

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Transcription factors play a key role in lineage commitment and differentiation of stem cells into distinct mature cells. In hematopoiesis, they regulate lineage-specific gene expression in a stage-specific manner through various physical and functional interactions with regulatory proteins that are simultanously recruited and activated to ensure timely gene expression. The transcription factor CCAAT/enhancer binding protein α (C/EBPα) is such a factor and is essential for the development of granulocytic/monocytic cells. The activity of C/EBPα is regulated on several levels including gene expression, alternative translation, protein interactions and posttranslational modifications, such as phosphorylation. In particular, the phosphorylation of serine 248 of the transactivation domain has been shown to be of crucial importance for granulocytic differentiation of 32Dcl3 cells in vitro.
Original languageEnglish
JournalP L o S One
Volume7
Issue number6
Pages (from-to)e38841
ISSN1932-6203
DOIs
Publication statusPublished - 2012

ID: 36840304