Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital

Phospho-ERK levels as predictors for chemotherapy of rectal carcinoma

Research output: Contribution to journalJournal articleResearchpeer-review

  1. Correction: Calcium electroporation for treatment of sarcoma in preclinical studies

    Research output: Contribution to journalJournal articleResearch

  2. Expression and function of Kv1.3 channel in malignant T cells in Sézary syndrome

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Real-world evidence to guide healthcare policies in oncology

    Research output: Contribution to journalJournal articleResearchpeer-review

View graph of relations

Treatment of rectal cancer has been vastly improved by advances in surgery and radiochemotherapy but remains an important cause of morbidity and mortality worldwide. A particular problem is the lack of predictive markers that can help to individualize treatment. The growth- and apoptosis-regulating signaling molecules ERK 1 and 2 are important to cancer growth and progression. They are activated through phosphorylation, which is initiated by a cascade involving the EGF receptor and RAS as upstream regulators. Moreover, in vitro studies indicate that phospho-ERKs interfere with 5-fluorouracil-based chemotherapy. Recently, we showed that high levels of phospho-ERKs in rectal cancer cells predict poor responses to neoadjuvant (preoperative) radiochemotherapy. We now report that preoperative phospho-ERK levels also can subdivide high-risk rectal cancer patients into a favorable and a poor prognostic group with respect to recurrence-free survival. Importantly, phospho-ERK levels were of predictive significance only in high-risk patients, who received adjuvant (postoperative) chemotherapy, but not in high-risk patients not receiving such therapy. Our results suggest that high cancer cell levels of phospho-ERK predict poor responsiveness to both preoperative and postoperative chemotherapy of rectal cancer.

Original languageEnglish
Issue number18
Pages (from-to)1745-1755
Number of pages11
Publication statusPublished - 1 Mar 2019

ID: 56892149