Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital

Phosphatidylcholine and its relation to apolipoproteins A-1 and B changes after Roux-en-Y gastric bypass: a cohort study

Research output: Contribution to journalJournal articleResearchpeer-review

  1. The trans fatty acid elaidate affects the global DNA methylation profile of cultured cells and in vivo

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Skeletal muscle structural lipids improve during weight-maintenance after a very low calorie dietary intervention

    Research output: Contribution to journalJournal articleResearchpeer-review

View graph of relations

BACKGROUND: Phosphatidylcholine (PC), the most abundant of the phospholipids, has several metabolic functions in organs such as the liver and the intestine, important structural- and signaling functions in biological membranes, and might have a role in the effects of Roux-en-Y gastric bypass (RYGB), an operation known to ameliorate metabolic diseases, including type 2 diabetes. We hypothesized that serum PC, as a reflection of phospholipid metabolism, changes after RYGB, and that changes are related to weight loss and possibly to changes in glucose metabolism (reflected in the HbA1c-level) as well as to changes in serum Apo A1, Apo B and Apo B/Apo A1 ratio.

METHODS: In a cohort of 220 RYGB patients, we studied changes in serum PC after RYGB in relation to serum Apo A1 and Apo B, the main apolipoproteins in HDL- and LDL/VLDL-particles, respectively, up to 2 years following RYGB-surgery.

RESULTS: Serum PC reached its lowest levels 3 months postoperatively to later rebound to preoperative levels 24 months after RYGB. No difference was seen between patients with or without type 2 diabetes. Serum Apo A1 showed a similar pattern whereas serum Apo B concentrations stayed low after the initial decrease after RYGB. As a result, the Apo B / Apo A1 ratio constantly decreased during follow-up. There was a strong positive correlation between PC and Apo A1, and between PC and Apo B, but none between Apo A1 and Apo B. After RYGB surgery, both PC and Apo A1, but not Apo B, correlated positively to weight loss. In relation to total cholesterol, the molar ratio between serum PC and plasma cholesterol increased steadily after RYGB.

CONCLUSIONS: We conclude that changes in PC and apolipoproteins after RYGB are highly dynamic, reflecting a large plasticity and capability of accommodating lipid metabolism including PC-, cholesterol- and apolipoprotein metabolism imposed by RYGB surgery, independent of glucose tolerance. We suggest that after RYGB and major weight loss, PC and Apo A1 might have a special role in the altered metabolism of lipoproteins.

Original languageEnglish
Article number169
JournalLipids in Health and Disease
Issue number1
Number of pages11
Publication statusPublished - 5 Sep 2019

    Research areas

  • Apolipoproteins, Clinical research, Diabetes, Gastric bypass surgery, Human, Obesity, Phosphatidylcholine, Phospholipids

ID: 57916758