Research
Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital
Published

Phenylephrine increases near-infrared spectroscopy determined muscle oxygenation during head-up tilt in men

Research output: Contribution to journalJournal articleResearchpeer-review

  1. Platelet function in lung cancer patients undergoing lobectomy

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Platelet increment is not associated with endothelial damage in haematological patients: a prospective observational study

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Change in HbA1c concentration as decision parameter for frequency of HbA1c measurement

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Relation between invasive hemodynamics and measured glomerular filtration rate by 51Cr-EDTA clearance in advanced heart failure

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Validation of plasma thyroxine and triiodothyronine methods on the ADVIA Centaur® XP

    Research output: Contribution to journalJournal articleResearchpeer-review

  1. Use of Low-Dose Aspirin and Mortality After Prostate Cancer Diagnosis: A Nationwide Cohort Study

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Role of spleen and liver for enhanced hemostatic competence following administration of adrenaline to humans

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Shoulder kinematics and kinetics of team handball throwing: A scoping review

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Hypoxia-induced vagal withdrawal is independent of the hypoxic ventilatory response in men

    Research output: Contribution to journalJournal articleResearchpeer-review

View graph of relations

Phenylephrine is an α-adrenergic agent and yet seems to increase near-infrared spectroscopy determined muscle oxygenation (SmO2) that reflects the ratio between oxygenated (O2Hb) and deoxygenated (Hb) haemoglobin/myoglobin. We examined whether the increase in SmO2 by phenylephrine reflects veno-constriction and to secure filling of the veins, subjects were exposed to head-up tilt (HUT). Phenylephrine (0.2 mg) was administered to 10 healthy males (24 years (22-27; median with interquartile range)) during 40° HUT with SmO2, O2Hb and Hb determined for the biceps brachii and vastus lateralis muscles. Changes in red cell volume within the thorax and thigh were evaluated by electrical admittance and brachial vein diameter determined by ultrasound. HUT accumulated blood in arms and legs as indicated by reduced thoracic and conversely enhanced thigh electrical admittance. Both over the arm and leg, HUT reduced SmO2 as a consequence of reduced O2Hb and increased Hb (p < .05). After 5 min HUT, phenylephrine increased MAP and total peripheral resistance, and both arm and thigh SmO2 increased due to a decrease in Hb and an increase in O2Hb. The results confirm that SmO2 decreases during HUT and demonstrate venous filling in the limbs. Furthermore, vasoconstriction during HUT is indicated by a decrease in O2Hb. Conversely, phenylephrine increased SmO2 likely illustrating increased muscle blood flow and venoconstriction as O2Hb increased while Hb was reduced.

Original languageEnglish
JournalScandinavian Journal of Clinical and Laboratory Investigation
Volume78
Issue number7-8
Pages (from-to)601-605
Number of pages5
ISSN0036-5513
DOIs
Publication statusPublished - 20 Oct 2018

ID: 56578889