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Phenotypic characterisation of immune cell infiltrates in testicular germ cell neoplasia

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  1. Plasma YKL-40 during pregnancy and gestational diabetes mellitus

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  2. The presence of HLA-antibodies in recurrent miscarriage patients is associated with a reduced chance of a live birth

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  3. The impact of anti-HY responses on outcome in current and subsequent pregnancies of patients with recurrent pregnancy losses

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  1. A Polygenic Risk Score Suggests Shared Genetic Architecture of Voice Break With Early Markers of Pubertal Onset in Boys

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  2. Bone mineral density is preserved in men with idiopathic infertility

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  3. CENTRAL PRECOCIOUS PUBERTY IN TWO BOYS WITH PRADER-WILLI SYNDROME ON GROWTH HORMONE TREATMENT

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  4. Author Correction: Characterisation and localisation of the endocannabinoid system components in the adult human testis

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Immune cells often infiltrate testicular germ cell neoplasms, including pre-invasive carcinoma in situ (CIS), but the significance of this phenomenon remains unknown. The composition and distribution of infiltrating immune cells were examined by immunohistochemistry in testis samples with CIS and overt seminoma, in comparison to biopsies from infertile men without neoplasia. The composition of immune cells was similar across all the groups studied. Macrophages, CD8(+) and CD45R0(+) T lymphocytes constituted the majority of infiltrates, B lymphocytes were present in an intermediate proportion and very few CD4(+) and FoxP3(+) T cells were detected. HLA-I antigen was more abundant in Sertoli cells in tubules containing CIS than in those with normal spermatogenesis. This study showed a phenotypically comparable composition of infiltrating immune cells independently of the presence of neoplasia, suggesting the absence of active immune surveillance in testicular germ cell cancer.
Original languageEnglish
JournalJournal of Reproductive Immunology
Volume100
Issue number2
Pages (from-to)135-45
ISSN0165-0378
DOIs
Publication statusPublished - 14 Nov 2013

ID: 41676943