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Phenotypic and functional plasticity of cells of innate immunity: macrophages, mast cells and neutrophils

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Galli, Stephen J ; Borregaard, Niels ; Wynn, Thomas A. / Phenotypic and functional plasticity of cells of innate immunity: macrophages, mast cells and neutrophils. In: Nature Immunology. 2011 ; Vol. 12, No. 11. pp. 1035-44.

Bibtex

@article{1c047dbc3aa94d11a76ff4c6d8ad5f94,
title = "Phenotypic and functional plasticity of cells of innate immunity: macrophages, mast cells and neutrophils",
abstract = "Hematopoietic cells, including lymphoid and myeloid cells, can develop into phenotypically distinct 'subpopulations' with different functions. However, evidence indicates that some of these subpopulations can manifest substantial plasticity (that is, undergo changes in their phenotype and function). Here we focus on the occurrence of phenotypically distinct subpopulations in three lineages of myeloid cells with important roles in innate and acquired immunity: macrophages, mast cells and neutrophils. Cytokine signals, epigenetic modifications and other microenvironmental factors can substantially and, in some cases, rapidly and reversibly alter the phenotype of these cells and influence their function. This suggests that regulation of the phenotype and function of differentiated hematopoietic cells by microenvironmental factors, including those generated during immune responses, represents a common mechanism for modulating innate or adaptive immunity.",
keywords = "Adaptive Immunity, Animals, Cell Differentiation, Cell Lineage, Cytokines, Epigenesis, Genetic, Gene Expression Regulation, Humans, Immunity, Innate, Macrophages, Mast Cells, Myeloid Progenitor Cells, Neutrophils, Signal Transduction, Stem Cell Niche",
author = "Galli, {Stephen J} and Niels Borregaard and Wynn, {Thomas A}",
year = "2011",
doi = "10.1038/ni.2109",
language = "English",
volume = "12",
pages = "1035--44",
journal = "Nature Immunology",
issn = "1529-2908",
publisher = "Nature Publishing Group",
number = "11",

}

RIS

TY - JOUR

T1 - Phenotypic and functional plasticity of cells of innate immunity: macrophages, mast cells and neutrophils

AU - Galli, Stephen J

AU - Borregaard, Niels

AU - Wynn, Thomas A

PY - 2011

Y1 - 2011

N2 - Hematopoietic cells, including lymphoid and myeloid cells, can develop into phenotypically distinct 'subpopulations' with different functions. However, evidence indicates that some of these subpopulations can manifest substantial plasticity (that is, undergo changes in their phenotype and function). Here we focus on the occurrence of phenotypically distinct subpopulations in three lineages of myeloid cells with important roles in innate and acquired immunity: macrophages, mast cells and neutrophils. Cytokine signals, epigenetic modifications and other microenvironmental factors can substantially and, in some cases, rapidly and reversibly alter the phenotype of these cells and influence their function. This suggests that regulation of the phenotype and function of differentiated hematopoietic cells by microenvironmental factors, including those generated during immune responses, represents a common mechanism for modulating innate or adaptive immunity.

AB - Hematopoietic cells, including lymphoid and myeloid cells, can develop into phenotypically distinct 'subpopulations' with different functions. However, evidence indicates that some of these subpopulations can manifest substantial plasticity (that is, undergo changes in their phenotype and function). Here we focus on the occurrence of phenotypically distinct subpopulations in three lineages of myeloid cells with important roles in innate and acquired immunity: macrophages, mast cells and neutrophils. Cytokine signals, epigenetic modifications and other microenvironmental factors can substantially and, in some cases, rapidly and reversibly alter the phenotype of these cells and influence their function. This suggests that regulation of the phenotype and function of differentiated hematopoietic cells by microenvironmental factors, including those generated during immune responses, represents a common mechanism for modulating innate or adaptive immunity.

KW - Adaptive Immunity

KW - Animals

KW - Cell Differentiation

KW - Cell Lineage

KW - Cytokines

KW - Epigenesis, Genetic

KW - Gene Expression Regulation

KW - Humans

KW - Immunity, Innate

KW - Macrophages

KW - Mast Cells

KW - Myeloid Progenitor Cells

KW - Neutrophils

KW - Signal Transduction

KW - Stem Cell Niche

U2 - 10.1038/ni.2109

DO - 10.1038/ni.2109

M3 - Journal article

VL - 12

SP - 1035

EP - 1044

JO - Nature Immunology

JF - Nature Immunology

SN - 1529-2908

IS - 11

ER -

ID: 33231243