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Phenotype Development in Adolescents With Tourette Syndrome: A Large Clinical Longitudinal Study

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DOI

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  1. Reappraisal is an effective emotion regulation strategy in children with Tourette syndrome and ADHD

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  2. Predictors of the Clinical Course of Tourette Syndrome: A Longitudinal Study

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Tourette syndrome (TS) is a neurodevelopmental disorder characterized by frequent comorbidities and a wide spectrum of phenotype presentations. This study aimed to describe the development of phenotypes in TS and tic-related impairment in a large longitudinal study of 226 children and adolescents followed up after 6 years. The participants were clinically examined to assess tic severity and impairment, obsessive compulsive disorder (OCD), and attention-deficit/hyperactivity disorder (ADHD). The development in phenotypes changed toward less comorbidity with 40% TS-only (no OCD or ADHD) (TS without OCD or ADHD) at baseline and 55% at follow-up.Tic-related impairment was expected to improve with an age-related tic decline, but surprisingly the impairment score did not reflect the tic decline. Sex, vocal and motor tics, and OCD and ADHD severity were highly significantly correlated to the impairment score. Knowledge of TS phenotype development is used in clinical settings to guide patients and for genetic, etiological, and clinical research purposes.

Original languageEnglish
JournalJournal of Child Neurology
Volume32
Issue number13
Pages (from-to)1047-1057
Number of pages11
ISSN0883-0738
DOIs
Publication statusPublished - Nov 2017

    Research areas

  • Journal Article

ID: 52673859