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The Capital Region of Denmark - a part of Copenhagen University Hospital
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Pharmacological migraine provocation: a human model of migraine

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  1. Parasagittal meningiomas

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  2. Chronic inflammatory demyelinative polyneuropathy

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  3. Lyme neuroborreliosis

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  4. Neurophysiological approach to disorders of peripheral nerve

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  5. Preface

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  1. The chronobiology of migraine: a systematic review

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  2. PEARL study protocol: a real-world study of fremanezumab effectiveness in patients with chronic or episodic migraine

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  3. Opening of BKCa channels causes migraine attacks: a new downstream target for the treatment of migraine

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  4. Erenumab prevents the occurrence of migraine attacks and not just migraine days: Post-hoc analyses of a phase III study

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  5. Guidelines of the International Headache Society for clinical trials with neuromodulation devices for the treatment of migraine

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In vitro studies have contributed to the characterization of receptors in cranial blood vessels and the identification of possible new antimigraine agents. Animal models enable the study of vascular responses, neurogenic inflammation, and peptide release, and thus have provided leads in the search for migraine mechanisms. So far, however, animal models cannot predict the efficacy of new therapies for migraine. Because migraine attacks are fully reversible and can be aborted by therapy, the headache- or migraine-provoking property of naturally occurring signaling molecules can be tested in a human model. If a naturally occurring substance can provoke migraine in human patients, then it is likely, although not certain, that blocking its effect will be effective in the treatment of acute migraine attacks. To this end, a human in vivo model of experimental headache and migraine in humans has been developed. This model has predicted the efficacy of nitric oxide synthase inhibition and calcitonin gene-related peptide receptor blockade, and has been used to examine other endogenous signaling molecules as well as genetic susceptibility factors.
Original languageEnglish
Book seriesHandbook of Clinical Neurology
Volume97
Pages (from-to)773-9
Number of pages7
ISSN0072-9752
DOIs
Publication statusPublished - 1 Jan 2010

ID: 32339301