TY - JOUR
T1 - Pharmacological interventions for co-occurring psychopathology in people with borderline personality disorder
T2 - secondary analysis of the Cochrane systematic review with meta-analyses
AU - Pereira Ribeiro, Johanne
AU - Juul, Sophie
AU - Kongerslev, Mickey T
AU - Jørgensen, Mie Sedoc
AU - Völlm, Birgit A
AU - Edemann-Callesen, Henriette
AU - Sales, Christian
AU - Schaug, Julie P
AU - Lieb, Klaus
AU - Simonsen, Erik
AU - Stoffers-Winterling, Jutta M
AU - Storebø, Ole Jakob
PY - 2024/10/21
Y1 - 2024/10/21
N2 - BACKGROUND: Medications are commonly used to treat co-occurring psychopathology in persons with borderline personality disorder (BPD).AIMS: To systematically review and integrate the evidence of medications for treatment of co-occurring psychopathology in people with BPD, and explore the role of comorbidities.METHOD: Building on the current Cochrane review of medications in BPD, an update literature search was done in March 2024. We followed the methods of this Cochrane review, but scrutinised all identified placebo-controlled trials post hoc for reporting of non BPD-specific ('co-occurring') psychopathology, and explored treatment effects in subgroups of samples with and without defined co-occurring disorders. GRADE ratings were done to assess the evidence certainty.RESULTS: Twenty-two trials were available for quantitative analyses. For antipsychotics, we found very-low-certainty evidence (VLCE) of an effect on depressive symptoms (standardised mean difference (SMD) -0.22, P = 0.04), and low-certainty evidence (LCE) of an effect on psychotic-dissociative symptoms (SMD -0.28, P = 0.007). There was evidence of effects of anticonvulsants on depressive (SMD -0.44, P = 0.02; LCE) and anxious symptoms (SMD -1.11, P < 0.00001; VLCE). For antidepressants, no significant findings were observed (VLCE). Exploratory subgroup analyses indicated a greater effect of antipsychotics in samples including participants with co-occurring substance use disorders on psychotic-dissociative symptoms (P = 0.001).CONCLUSIONS: Our findings, based on VLCE and LCE only, do not support the use of pharmacological interventions in people with BPD to target co-occurring psychopathology. Overall, the current evidence does not support differential treatment effects in persons with versus without defined comorbidities. Medications should be used cautiously to target co-occurring psychopathology.
AB - BACKGROUND: Medications are commonly used to treat co-occurring psychopathology in persons with borderline personality disorder (BPD).AIMS: To systematically review and integrate the evidence of medications for treatment of co-occurring psychopathology in people with BPD, and explore the role of comorbidities.METHOD: Building on the current Cochrane review of medications in BPD, an update literature search was done in March 2024. We followed the methods of this Cochrane review, but scrutinised all identified placebo-controlled trials post hoc for reporting of non BPD-specific ('co-occurring') psychopathology, and explored treatment effects in subgroups of samples with and without defined co-occurring disorders. GRADE ratings were done to assess the evidence certainty.RESULTS: Twenty-two trials were available for quantitative analyses. For antipsychotics, we found very-low-certainty evidence (VLCE) of an effect on depressive symptoms (standardised mean difference (SMD) -0.22, P = 0.04), and low-certainty evidence (LCE) of an effect on psychotic-dissociative symptoms (SMD -0.28, P = 0.007). There was evidence of effects of anticonvulsants on depressive (SMD -0.44, P = 0.02; LCE) and anxious symptoms (SMD -1.11, P < 0.00001; VLCE). For antidepressants, no significant findings were observed (VLCE). Exploratory subgroup analyses indicated a greater effect of antipsychotics in samples including participants with co-occurring substance use disorders on psychotic-dissociative symptoms (P = 0.001).CONCLUSIONS: Our findings, based on VLCE and LCE only, do not support the use of pharmacological interventions in people with BPD to target co-occurring psychopathology. Overall, the current evidence does not support differential treatment effects in persons with versus without defined comorbidities. Medications should be used cautiously to target co-occurring psychopathology.
KW - clinical trials
KW - Comorbidity
KW - mental health services
KW - personality disorders
KW - pharmaceutical drug trial
UR - http://www.scopus.com/inward/record.url?scp=85207767562&partnerID=8YFLogxK
U2 - 10.1192/bjp.2024.172
DO - 10.1192/bjp.2024.172
M3 - Review
C2 - 39428384
SN - 0007-1250
SP - 1
EP - 12
JO - The British journal of psychiatry : the journal of mental science
JF - The British journal of psychiatry : the journal of mental science
ER -