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Pharmacological attenuation of myocardial reperfusion injury in a closed-chest porcine model: a systematic review

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  1. Amiodarone Treatment in the Early Phase of Acute Myocardial Infarction Protects Against Ventricular Fibrillation in a Porcine Model

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  2. Hypertrophy signaling pathways in experimental chronic aortic regurgitation

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  1. Safety of early ileostomy closure: a systematic review and meta-analysis of randomized controlled trials

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  2. Melatonin for preoperative and postoperative anxiety in adults

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  3. More than one-third of Cochrane reviews had gift authors, whereas ghost authorship was rare

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  4. Duration of early systolic lengthening: prognostic potential in the general population

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Myocardial ischemia-reperfusion injury is a clinical challenge in interventional cardiology, and at the moment, no pharmacological agent is universally accepted in the prevention. In order to prevent inappropriate clinical trials, a potential pharmacological agent should be proved reproducibly effective in clinically relevant experimental studies before initiation of human studies. The closed-chest porcine model is a promising experimental model of ischemia-reperfusion injury. The purpose of this systematic review was to describe the pharmacological treatments evaluated in the closed-chest porcine model and discuss different aspects of the model for future use. The systematic review was performed according to the PRISMA guidelines.

Original languageEnglish
JournalJournal of Cardiovascular Translational Research
Volume7
Issue number6
Pages (from-to)570-80
Number of pages11
ISSN1937-5387
DOIs
Publication statusPublished - Aug 2014

ID: 44542857