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The Capital Region of Denmark - a part of Copenhagen University Hospital
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Pharmacologic resuscitation for hemorrhagic shock combined with traumatic brain injury

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  1. Reliable and valid assessment of procedural skills in resuscitative endovascular balloon occlusion of the aorta (REBOA)

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  2. The Geriatric Nutritional Risk Index is a powerful predictor of adverse outcome in the elderly emergency surgery patient

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  3. Identification of a new genetic variant associated with cholecystitis: a multicenter genome-wide association study

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  4. Most of the variation in length of stay in emergency general surgery is not related to clinical factors of patient care

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  1. A characterization of trauma laparotomies in a scandinavian setting: an observational study

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  2. Pancreatic surgery during the COVID-19 pandemic 2020-2021: an observational cohort study from a third level referral center

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  3. Agreement Between Standard and ICD-10-Based Injury Severity Scores

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  4. Increased inflammatory markers in adult patients born with an atrial septal defect

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  • Guang Jin
  • Michael Duggan
  • Ayesha Imam
  • Marc A Demoya
  • Martin Sillesen
  • John Hwabejire
  • Cecilie H Jepsen
  • Baoling Liu
  • Ali Y Mejaddam
  • Jennifer Lu
  • William Michael Smith
  • George C Velmahos
  • Simona Socrate
  • Hasan B Alam
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We have previously demonstrated that valproic acid (VPA), a histone deacetylase inhibitor, can improve survival after hemorrhagic shock (HS), protect neurons from hypoxia-induced apoptosis, and attenuate the inflammatory response. We have also shown that administration of 6% hetastarch (Hextend [Hex]) after traumatic brain injury (TBI) decreases brain swelling, without affecting size of the lesion. This study was performed to determine whether addition of VPA to Hex would decrease the lesion size in a clinically relevant large animal model of TBI + HS.
Original languageEnglish
JournalThe journal of trauma and acute care surgery
Volume73
Issue number6
Pages (from-to)1461-70
Number of pages10
DOIs
Publication statusPublished - Dec 2012

    Research areas

  • Animals, Brain Injuries, Disease Models, Animal, Drug Therapy, Combination, Female, Hemodynamics, Hydroxyethyl Starch Derivatives, Inflammation, Isotonic Solutions, Resuscitation, Shock, Hemorrhagic, Swine, Valproic Acid

ID: 41960145