Pharmacologic resuscitation for hemorrhagic shock combined with traumatic brain injury

Guang Jin; Michael Duggan; Ayesha Imam; Marc A Demoya; Martin Sillesen; John Hwabejire; Cecilie H Jepsen; Baoling Liu; Ali Y Mejaddam; Jennifer Lu; William Michael Smith; George C Velmahos; Simona Socrate; Hasan B Alam

doi:10.1097/TA.0b013e3182782641

Pharmacologic resuscitation for hemorrhagic shock combined with traumatic brain injury

Guang Jin
, Michael Duggan
, Ayesha Imam
, Marc A Demoya
, Martin Sillesen
, John Hwabejire
, Cecilie H Jepsen
, Baoling Liu
, Ali Y Mejaddam
, Jennifer Lu
, William Michael Smith
, George C Velmahos
, Simona Socrate
, Hasan B Alam

Department of Anaesthesiology, Center of Head and Orthopaedic Surgery

65 Citations (Scopus)

Abstract

We have previously demonstrated that valproic acid (VPA), a histone deacetylase inhibitor, can improve survival after hemorrhagic shock (HS), protect neurons from hypoxia-induced apoptosis, and attenuate the inflammatory response. We have also shown that administration of 6% hetastarch (Hextend [Hex]) after traumatic brain injury (TBI) decreases brain swelling, without affecting size of the lesion. This study was performed to determine whether addition of VPA to Hex would decrease the lesion size in a clinically relevant large animal model of TBI + HS.

Original language	English
Journal	The journal of trauma and acute care surgery
Volume	73
Issue number	6
Pages (from-to)	1461-70
Number of pages	10
DOIs	https://doi.org/10.1097/TA.0b013e3182782641
Publication status	Published - Dec 2012

Keywords

Animals
Brain Injuries
Disease Models, Animal
Drug Therapy, Combination
Female
Hemodynamics
Hydroxyethyl Starch Derivatives
Inflammation
Isotonic Solutions
Resuscitation
Shock, Hemorrhagic
Swine
Valproic Acid

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Jin, G., Duggan, M., Imam, A., Demoya, M. A., Sillesen, M., Hwabejire, J., Jepsen, C. H., Liu, B., Mejaddam, A. Y., Lu, J., Smith, W. M., Velmahos, G. C., Socrate, S., & Alam, H. B. (2012). Pharmacologic resuscitation for hemorrhagic shock combined with traumatic brain injury. The journal of trauma and acute care surgery, 73(6), 1461-70. https://doi.org/10.1097/TA.0b013e3182782641

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title = "Pharmacologic resuscitation for hemorrhagic shock combined with traumatic brain injury",

abstract = "We have previously demonstrated that valproic acid (VPA), a histone deacetylase inhibitor, can improve survival after hemorrhagic shock (HS), protect neurons from hypoxia-induced apoptosis, and attenuate the inflammatory response. We have also shown that administration of 6\% hetastarch (Hextend [Hex]) after traumatic brain injury (TBI) decreases brain swelling, without affecting size of the lesion. This study was performed to determine whether addition of VPA to Hex would decrease the lesion size in a clinically relevant large animal model of TBI + HS.",

keywords = "Animals, Brain Injuries, Disease Models, Animal, Drug Therapy, Combination, Female, Hemodynamics, Hydroxyethyl Starch Derivatives, Inflammation, Isotonic Solutions, Resuscitation, Shock, Hemorrhagic, Swine, Valproic Acid",

author = "Guang Jin and Michael Duggan and Ayesha Imam and Demoya, \{Marc A\} and Martin Sillesen and John Hwabejire and Jepsen, \{Cecilie H\} and Baoling Liu and Mejaddam, \{Ali Y\} and Jennifer Lu and Smith, \{William Michael\} and Velmahos, \{George C\} and Simona Socrate and Alam, \{Hasan B\}",

year = "2012",

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doi = "10.1097/TA.0b013e3182782641",

language = "English",

volume = "73",

pages = "1461--70",

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T1 - Pharmacologic resuscitation for hemorrhagic shock combined with traumatic brain injury

AU - Jin, Guang

AU - Duggan, Michael

AU - Imam, Ayesha

AU - Demoya, Marc A

AU - Sillesen, Martin

AU - Hwabejire, John

AU - Jepsen, Cecilie H

AU - Liu, Baoling

AU - Mejaddam, Ali Y

AU - Lu, Jennifer

AU - Smith, William Michael

AU - Velmahos, George C

AU - Socrate, Simona

AU - Alam, Hasan B

PY - 2012/12

Y1 - 2012/12

N2 - We have previously demonstrated that valproic acid (VPA), a histone deacetylase inhibitor, can improve survival after hemorrhagic shock (HS), protect neurons from hypoxia-induced apoptosis, and attenuate the inflammatory response. We have also shown that administration of 6% hetastarch (Hextend [Hex]) after traumatic brain injury (TBI) decreases brain swelling, without affecting size of the lesion. This study was performed to determine whether addition of VPA to Hex would decrease the lesion size in a clinically relevant large animal model of TBI + HS.

AB - We have previously demonstrated that valproic acid (VPA), a histone deacetylase inhibitor, can improve survival after hemorrhagic shock (HS), protect neurons from hypoxia-induced apoptosis, and attenuate the inflammatory response. We have also shown that administration of 6% hetastarch (Hextend [Hex]) after traumatic brain injury (TBI) decreases brain swelling, without affecting size of the lesion. This study was performed to determine whether addition of VPA to Hex would decrease the lesion size in a clinically relevant large animal model of TBI + HS.

KW - Animals

KW - Brain Injuries

KW - Disease Models, Animal

KW - Drug Therapy, Combination

KW - Female

KW - Hemodynamics

KW - Hydroxyethyl Starch Derivatives

KW - Inflammation

KW - Isotonic Solutions

KW - Resuscitation

KW - Shock, Hemorrhagic

KW - Swine

KW - Valproic Acid

U2 - 10.1097/TA.0b013e3182782641

DO - 10.1097/TA.0b013e3182782641

M3 - Journal article

C2 - 23188239

SN - 2163-0763

VL - 73

SP - 1461

EP - 1470

JO - The journal of trauma and acute care surgery

JF - The journal of trauma and acute care surgery

IS - 6

ER -

Pharmacologic resuscitation for hemorrhagic shock combined with traumatic brain injury

Abstract

Keywords

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